{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:54:51Z","timestamp":1789707291760,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T00:00:00Z","timestamp":1334188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human papillomavirus (HPV) infection is a necessary cause of cervical cancer. The aim of this study was to estimate the prevalence of cervical HPV infection and HPV type\u2010specific distribution among women attending cervical cancer screening in Spain during 2007 and 2008. Women aged 18\u201365 years were recruited according to an age\u2010stratified sampling method. Liquid\u2010based cervical samples were collected and analyzed for cytology, HPV detection, and genotyping. HPV genotyping was determined using the INNO\u2010LiPA HPV Genotyping Extra Reverse Hybridization Line Probe Assay. Prevalence estimates were age\u2010standardized using 2001 Spanish census data. The present study included 3,261 women. Age\u2010standardized HC2\u2010based HPV prevalence was 14.3% (95% CI, 13.1\u201315.5) among women aged 18\u201365 years, and 28.8% (26.6\u201331.1) among women aged 18\u201325 years. High\u2010risk HPV types were detected in 12.2% (95% CI, 11.1\u201313.4) of HPV\u2010tested women, representing 84.0% of HPV\u2010positive samples. Multiple infections were present in 4.1% (95% CI, 3.4\u20134.8) of HPV\u2010tested women (25.0% of HPV\u2010positive samples). The most common high\u2010risk HPV\u2010types among HPV\u2010tested women were 16 (2.9%), 52 (1.8%), 51 (1.6%), 31 (1.3%), and 66 (1.2%). HPV\u2010type 16 was present in 16.9% of HPV\u2010positive samples. One or more of the HPV vaccine types 6\/11\/16\/18 were detected in 3.8% of HPV\u2010tested women (22.1% of HPV\u2010positive samples). Though not a true population\u2010based survey, this study provides valuable baseline data for future assessment of the impact of current HPV vaccination programs in Spain. The high prevalence of HPV infection among young women may reflect recent changes in sexual behavior. J. Med. 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