{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T05:42:34Z","timestamp":1696830154139},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T00:00:00Z","timestamp":1336953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Considering the limitations of cytology for detection of residual cervical cancer after radiotherapy, the aim of this study was to evaluate the frequency and viral load of high\u2010risk HPV in cervical and vaginal samples during the early follow\u2010up of patients treated for invasive cervical cancer and correlate the results with cytological examination. Conventional cytology and hybrid capture test were performed on cervical and vaginal samples of 52 women with invasive cervical carcinoma 3 months after therapy. High\u2010risk HPV was detected in 46.1% of the samples and the median and the range of the ratio relative light unit (RLU)\/cutoff (CO) (estimated viral load) in positive samples was 1.71 (1\u20132120.03). No significant difference was observed in viral frequency and in median of the ratio RLU\/CO between samples of patients at different stages (I\u2013III) and between cervical samples, from patients treated by exclusive radiotherapy with or without chemotherapy, and vaginal samples, from patients who underwent to hysterectomy and radiotherapy with or without chemotherapy. Cytological abnormalities were more frequent significantly in samples with HPV than in samples without HPV. The viral load was also higher significantly in samples with cytological abnormalities when compared with the samples without cytological abnormalities. In conclusion, HPV detection methods may be useful during the early follow\u2010up as a complement to conventional cytology for the diagnosis of residual cervical cancer after radiotherapy. J. Med. Virol. 84: 1115\u20131119, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23303","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T15:05:08Z","timestamp":1337007908000},"page":"1115-1119","source":"Crossref","is-referenced-by-count":6,"title":["Association between human papillomavirus infection and cytological abnormalities during early follow\u2010up of invasive cervical cancer"],"prefix":"10.1002","volume":"84","author":[{"given":"Ana Em\u00edlia Borges","family":"de Azevedo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Pirani","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flor\u00eancio Figueiredo Cavalcante","family":"Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anam\u00e9lia 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