{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:26:23Z","timestamp":1759159583823},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T00:00:00Z","timestamp":1336953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human enteroviruses are the most common cause of viral meningitis. Viral\u2013bacterial interaction may affect the clinical course and outcome of bacterial meningitis. In Africa, viruses might be responsible for 14\u201325% of all meningitis cases. However, only few studies from Africa have reported detection of viruses in the cerebrospinal fluid (CSF) or mixed viral\u2013bacterial infections of the central nervous system (CNS). The aim of the present study was to investigate the presence of picornaviruses in the CSF of children suffering from meningitis in Luanda, Angola. The study included 142 consecutive children enrolled in a prospective study of bacterial meningitis in Luanda between 2005 and 2006, from whom a CSF sample was available. CSF samples were obtained at hospital admission, stored in a deep\u2010freeze, and transported to Finland for testing by real\u2010time PCR for picornaviruses. Enteroviruses were detected in 4 (3%) of 142 children with presumed bacterial meningitis. A 5\u2010month\u2010old girl with rhinovirus and <jats:italic>Haemophilus influenzae<\/jats:italic> meningitis recovered uneventfully. An 8\u2010year\u2010old girl with human enterovirus and pneumococcal meningitis developed no sequelae. A 2\u2010month\u2010old girl with human enterovirus and malaria recovered quickly. A 7\u2010month\u2010old girl with human enterovirus was treated for presumed tuberculous meningitis and survived with severe sequelae. Mixed infections of the CNS with picornaviruses and bacteria are rare. Detection of an enterovirus does not affect the clinical picture and outcome of bacterial meningitis. J. Med. Virol. 84: 1080\u20131083, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23304","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T15:05:08Z","timestamp":1337007908000},"page":"1080-1083","source":"Crossref","is-referenced-by-count":20,"title":["Picornaviruses in cerebrospinal fluid of children with meningitis in Luanda, Angola"],"prefix":"10.1002","volume":"84","author":[{"given":"Tuula","family":"Pelkonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmeli","family":"Roine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabete","family":"Anjos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Kaijalainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merja","family":"Roivainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Peltola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Pitk\u00e4ranta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200406000-00003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04897-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.02.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/599094"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(98)00048-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268807000271"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3280ad4672"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095026880005706X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00277-08"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70055-X"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/v1031178"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70139-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.4269\/ajtmh.2006.75.1148","article-title":"Role of viruses in Kenyan children presenting with acute encephalopathy in a malaria\u2010endemic area","volume":"75","author":"Schubart CD","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_6_15_1","first-page":"552","article-title":"Simultaneous recovery of bacterial and viral pathogens from cerebrospinal fluid","volume":"7","author":"Sferra TJ","year":"1988","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/INF.0b013e3181cdafc2","article-title":"Viral coinfections in children with invasive pneumococcal disease","volume":"29","author":"Techasaensiri B","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/426402"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/589752"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.23304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.23304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T20:17:22Z","timestamp":1696796242000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.23304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,14]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1002\/jmv.23304"],"URL":"https:\/\/doi.org\/10.1002\/jmv.23304","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,14]]}}}