{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:14:41Z","timestamp":1700612081955},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T00:00:00Z","timestamp":1344988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HBV genotype may correlate with outcome and treatment response. Genotype has been compared with treatment response in children infected perinatally with hepatitis B following treatment with oral antiviral drugs (lamivudine or adefovir) or interferon (IFN) alone and with prednisolone priming (Pred\/IFN). All children who took part in clinical trials in this unit since 1990 were included. Hepatitis B genotypes were determined by direct sequencing or using a commercial line probe assay (InnoLipa). Sixty\u2010five children were included; 20 were treated with IFN; 19 with Pred\/IFN; 22 with lamivudine and 7 with adefovir, some took part in more than one treatment study. 63 out of 65 children were clearly typed into single genotypes; 16, 7, 3, and 37 typing as A, B, C, and D respectively. The majority of South\u2010Asian children had genotype D and European and Afro\u2010Caribbean children were more likely to have genotype A. Treatment response (seroconversion from HBeAg to Anti\u2010HBe) was better in children with genotypes A [n\u2009=\u200916] and D [n\u2009=\u200937] (55.5% and 48.7%), compared to those with B [n\u2009=\u20097] and C [n\u2009=\u20093] (12.5% and 0%) for all treatments. The response to interferon alone was better in children with genotype A compared to D (50% and 36%), but prednisolone priming improved the response so that there was no difference between genotypes A and D (66.7% and 70%). Assessment of genotype in children pre\u2010treatment may provide a guide to potential response. The response to treatment by genotype should be evaluated in future clinical trials in children. J. Med. Virol. 84:1535\u20131540, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23308","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T17:06:44Z","timestamp":1346173604000},"page":"1535-1540","source":"Crossref","is-referenced-by-count":2,"title":["Does genotype predict response to treatment in children infected with hepatitis B perinatally?"],"prefix":"10.1002","volume":"84","author":[{"given":"Elizabeth","family":"Boxall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaswant","family":"Sira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamima","family":"Kaskar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Workman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,15]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"757","volume-title":"Viral hepatitis and liver disease","author":"Boxall EH","year":"1990"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.009837"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20637"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33588"},{"key":"e_1_2_6_6_1","first-page":"1425","article-title":"HBV genotype B is associated with better response to interferon therapy in HBeAg(+) chronic hepatitis than genotype C","volume":"36","author":"Chu CJ","year":"2002","journal-title":"Hepatology"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2010.01326.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6118.949"},{"key":"e_1_2_6_9_1","first-page":"43","article-title":"Hepatitis B virus genotypes and response to antiviral therapy","volume":"52","author":"Enomoto M","year":"2006","journal-title":"Clin Lab"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.060327"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840400407"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230407"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20935"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22250"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80135-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.09.036"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.010"},{"key":"e_1_2_6_18_1","first-page":"108","article-title":"HBsAg clearance continues to increase after end of treatment with Pegasys\u2009\u00b1\u2009lamivudine: 5 year follow up study","volume":"3","author":"Marcellin P","year":"2009","journal-title":"Hepatol Int"},{"key":"e_1_2_6_19_1","unstructured":"NICE Guidance: TA96 Hepatitis B (chronic)\u2014adefovir dipivoxil and pegylated interferon alpha\u20102a: Guidance 23 February 2006."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pap.0000249927.67907.eb"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm362"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37041"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(04)90045-1"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70318-X"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.3.590-597.2000"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21020"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-1-67"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.07.017"},{"key":"e_1_2_6_29_1","first-page":"211","article-title":"Should treatment of hepatitis B depend on hepatitis B virus genotypes? 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