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In the study, which included both the largest number of laryngeal papilloma tissue specimens (152 specimens from 152 patients) to date and the largest number of prospectively collected and histologically confirmed tissue specimens of anogenital warts obtained from both genders (422 specimens from 315 patients), HPV DNA was detected in 413\/422 (97.9%) of anogenital warts and 139\/152 (91.4%) of laryngeal papillomas. HPV\u20106 and\/or HPV\u201011 were detected in 291\/315 (92.4%) patients with anogenital warts and in 138\/152 (90.8%) patients with laryngeal papillomas, indicating that the great majority of both tumors could be prevented with prophylactic quadrivalent vaccine. The HPV\u20106 gender\u2010specific distribution in both anogenital warts and laryngeal papillomas was not statistically significant. In contrast, HPV\u201011 was found almost three times more often in males than in females with anogenital warts (16.5% vs. 6.3%; <jats:italic>P<\/jats:italic>\u2009=\u20090.008), with a gender neutral HPV\u201011 type distribution in laryngeal papillomas. The overall HPV DNA prevalence in anogenital warts was significantly different from that in laryngeal papillomas (97.1% vs. 91.4%; <jats:italic>P<\/jats:italic>\u2009=\u20090.01). In the first comparison of the HPV\u20106\/HPV\u201011 type\u2010specific distribution between patients suffering from anogenital warts and laryngeal papillomas with the same geographic and ethnic background, a significant imbalance in tumor\u2010specific distribution of HPV\u20106 and HPV\u201011 was identified: HPV\u20106 was statistically more often present in anogenital warts than in laryngeal papillomas (79.0% vs. 59.2%; <jats:italic>P<\/jats:italic>\u2009=\u20090.000013), whereas HPV\u201011 was statistically more frequent in laryngeal papillomas than in anogenital warts (28.9% vs. 12.4%; <jats:italic>P<\/jats:italic>\u2009=\u20090.00003). J. Med. Virol. 84: 1233\u20131241, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23318","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T02:28:29Z","timestamp":1340072909000},"page":"1233-1241","source":"Crossref","is-referenced-by-count":57,"title":["Tumor\u2010specific and gender\u2010specific pre\u2010vaccination distribution of human papillomavirus types 6 and 11 in anogenital warts and laryngeal papillomas: A study on 574 tissue specimens"],"prefix":"10.1002","volume":"84","author":[{"given":"Kristina Fujs","family":"Komlo\u0161","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u0161tjan 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