{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T22:57:52Z","timestamp":1715986672476},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T00:00:00Z","timestamp":1339977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IL28B genotypes and virological response within 4 weeks are predictors of sustained virological response in patients infected with chronic hepatitis C virus (HCV) genotype 1 treated with antiviral dual combination therapy. The predictive value of \u201cearly\u201d anemia (within 4 weeks) alone or in combination with the two other predictors has not been studied yet. A total of 305 pegylated interferon\u2010\u03b1 and ribavirin\u2010treated patients with HCV genotype 1 were included in this study. Hemoglobin values at week 0, 4, 8, and 12 as well as the predictive efficiency of early anemia (hemoglobin value below the gender\u2010specific lower limit: female\u2009&lt;\u200911.5; male\u2009&lt;\u200913.5\u2009g\/dl) during therapy were assessed with IL28B genotypes and rapid virological response. Forty\u2010eight percent of treated patients developed early anemia. In both females and males (64%), a decrease of hemoglobin concentration of 3\u2009g\/dl (female: 14.7\u2009\u00b1\u20091.1 to 11.4\u2009\u00b1\u20091.3; male: 15.2\u2009\u00b1\u20091.2 to 12.2\u2009\u00b1\u20091.5) significantly correlated with sustained virological response. 64% of IL28B\u2010CC patients showed a sustained virological response. Seventy\u2010eight percent of patients with rapid virological response definitively eliminated the virus. Early anemia (81:48:41%) and rapid virological response (83:91:92%) increased the predictive efficiency of IL28B rs12979860 genotype distribution (CC:CT:TT). IL28B\u2010CC and early anemia as well as IL28B\u2010CC and rapid virological response had an Odds ratio of 42.4 or 75 to achieve a sustained virological response compared to TT without early anemia or rapid virological response. This finding may help to early identify responders to standard PEG\u2010IFN\u2010\u03b1 and ribavirin treatment even within those with unfavorable IL28B genotype. J. Med. Virol. 84: 1208\u20131216, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23323","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T02:28:29Z","timestamp":1340072909000},"page":"1208-1216","source":"Crossref","is-referenced-by-count":11,"title":["Early anemia and rapid virological response improve the predictive efficiency of IL28B\u2010genotype for treatment outcome to antiviral combination therapy in patients infected with chronic HCV genotype 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