{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:42:31Z","timestamp":1790048551600,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,7,18]],"date-time":"2012-07-18T00:00:00Z","timestamp":1342569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T\u2010lymphotropic virus type 1 (HTLV\u20101) is associated with adult T\u2010cell leukemia (ATL) and HTLV\u20101 associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) and has also been implicated in several disorders, including periodontal disease. The proviral load is an important biological marker for understanding HTLV\u20101 pathogenesis and elucidating whether or not the virus is related to the clinical manifestation of the disease. This study describes the oral health profile of HTLV\u20101 carriers and HAM\/TSP patients in order to investigate the association between the proviral load in saliva and the severity of the periodontal disease and to examine virus intra\u2010host variations from peripheral blood mononuclear cells and saliva cells. It is a cross\u2010sectional analytical study of 90 individuals carried out from November 2006 to May 2008. Of the patients, 60 were HTLV\u20101 positive and 30 were negative. Individuals from the HTLV\u20101 positive and negative groups had similar mean age and social\u2010economic status. Data were analyzed using two available statistical software packages, STATA 8.0 and SPSS 11.0 to conduct frequency analysis. Differences of <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 were considered statistically significant. HTLV\u20101 patients had poorer oral health status when compared to seronegative individuals. A weak positive correlation between blood and saliva proviral loads was observed. The mean values of proviral load in blood and saliva in patients with HAM\/TSP was greater than those in HTLV\u20101 carriers. The HTLV\u20101 molecular analysis from PBMC and saliva specimens suggests that HTLV\u20101 in saliva is due to lymphocyte infiltration from peripheral blood. A direct relationship between the proviral load in saliva and oral manifestations was observed. J. Med. Virol. 84:1428\u20131436, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23327","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T19:52:20Z","timestamp":1343073140000},"page":"1428-1436","source":"Crossref","is-referenced-by-count":14,"title":["Oral health profile in patients infected with HTLV\u20101: Clinical findings, proviral load, and molecular analysis from HTLV\u20101 in saliva"],"prefix":"10.1002","volume":"84","author":[{"given":"Liliane","family":"Lins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Jos\u00e9 Uchoa","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe Ferreira","family":"de Almeida Rego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochele","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Kashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana Nilla Olavarria","family":"Gallazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Tosta","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Galv\u00e3o\u2010Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos Junior","family":"Alcantara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000216383.14808.13"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1996.12.157"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1415-790X2001000200003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0482-50042005000200005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(01)00445-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200312150-00013"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1066-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37297203532.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/649871"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_6_12_1","unstructured":"GiozzaSP.2006.Manifesta\u00e7\u00f5es orais: Aspectos cl\u00ednicos e imunol\u00f3gicos em indiv\u00edduos portadores de HTLV\u20101. 2006. 117f. 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