{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:10:03Z","timestamp":1788826203693,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T00:00:00Z","timestamp":1350345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was performed to analyze epidemiological and molecular characteristics of coxsakievirus (CV) B1 infection associated with severe neonatal illness cases and death in Korea during 2008\u20132009. Through a nationwide surveillance program, specimens were collected from 104 patients infected with CVB1. The detection of enteroviruses (EVs) from specimens was subjected to a diagnostic real\u2010time polymerase chain reaction (RT\u2010PCR) in the 5\u2032\u2010non\u2010coding region (NCR). A semi\u2010nested PCR was conducted to amplify sequences from the VP1 region and sequence comparison was performed with reference strains registered in Genbank. Male\u2010to\u2010female ratio confirmed approximately 5:4. The major clinical manifestation of patients infected with CVB1 was aseptic meningitis (55.8%). The other clinical symptoms were herpangina or hand\u2013foot\u2013mouth disease (22.1%) and neonatal sepsis (7.7%). The sequences of CVB1 isolates were divided into four genetic clusters (A\u2013D) with at least 15% diversity between the clusters. Almost all the CVB1 isolates in Korea from 2008 to 2009 were in cluster D (except for 2 cases). The homology relationship was also similar between the Korean CVB1 strains and US strain (above 93%). It is possible that Korean CVB1 isolates found during 2008\u20132009 originated from the US strains found during 2006\u20132008. The identification of CVB1 in South Korea shows the potential of EVs to cause serious disease in an unpredictable fashion. J. Med. Virol. 85:110\u2013115, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23359","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T17:11:10Z","timestamp":1350407470000},"page":"110-115","source":"Crossref","is-referenced-by-count":17,"title":["Molecular characteristics of human coxsackievirus B1 infection in Korea, 2008\u20132009"],"prefix":"10.1002","volume":"85","author":[{"given":"HyeJin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byunghak","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seoyeon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoung","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaekeun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunhee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Seok","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kisang","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doo\u2010Sung","family":"Cheon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2009.04.010"},{"key":"e_1_2_5_3_1","first-page":"696","article-title":"A case of neonatal coxsackie B virus brainstem encephalitis","volume":"46","author":"Brecht M","year":"2010","journal-title":"J Paediatr Child Health"},{"key":"e_1_2_5_4_1","first-page":"553","article-title":"Increased detections and severe neonatal disease associated with coxsackievirus b1 infection\u2014United States, 2007","volume":"57","author":"Centers for Disease Control and Prevention (CDC)","year":"2008","journal-title":"MMWR"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.3.404"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-330"},{"key":"e_1_2_5_7_1","first-page":"371","article-title":"Neonatal coxsackievirus group B infections: Experience of a single department of neonatology","volume":"30","author":"Isacsohn M","year":"1994","journal-title":"Isr J Med Sci"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.22133"},{"key":"e_1_2_5_9_1","first-page":"294","article-title":"Updates on enterovirus surveillance in Korea","volume":"36","author":"Jee YM","year":"2004","journal-title":"Infect Chemother"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/5.6.1019"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000237798.07462.32"},{"key":"e_1_2_5_12_1","first-page":"1","article-title":"Enterovirus surveillance\u2014United States, 1970\u20132005","volume":"55","author":"Khetsuriani N","year":"2006","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.326"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(76)80808-6"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000091294.63706.f3"},{"key":"e_1_2_5_16_1","first-page":"1028","article-title":"Neonate with coxsackie B infection, cardiomyopathy and arrhythmias","volume":"97","author":"Lu JC","year":"2005","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2006.0085"},{"key":"e_1_2_5_18_1","first-page":"839","article-title":"Viral infections of toronto children during 1965. 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