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In this study, HIV\u20101 seropositive drug\u2010na\u00efve patients infected by heterosexual transmission were enrolled. The full length <jats:italic>gag<\/jats:italic> and <jats:italic>pol<\/jats:italic> genes were sequenced followed by phylogenetic analysis, recombinant analysis and drug resistant analysis. Multiple subtypes were identified, including CRF01_AE (80.1%), CRF07_BC (6.4%), CRF08_BC (10.2%), subtype B (1.7%), and URFs (1.7%). In the phylogenetic tree, two large CRF01_AE clusters were identified. One cluster is originating from Vietnam strains as being reported previously in intravenous drug users. One novel cluster was identified and showed close relationship to strains from Fujian province. Inter\u2010subtype recombination among CRF01_AE, subtype B and C was identified. Low level drug\u2010resistance in drug\u2010na\u00efve heterosexually transmitted infections was found. The results suggested that multiple originating CRF01_AE strains dominated the HIV\u20101 epidemic in heterosexual transmission in Guangxi province. J. Med. Virol. 85:388\u2013395, 2013.  \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23360","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T17:56:59Z","timestamp":1358877419000},"page":"388-395","source":"Crossref","is-referenced-by-count":30,"title":["Subtype CRF01_AE dominate the sexually transmitted human immunodeficiency virus type 1 epidemic in Guangxi, China"],"prefix":"10.1002","volume":"85","author":[{"given":"Lin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujia","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuoyi","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2007.0269"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004724"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2011.04.034"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/522008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181aac516"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6941.2006.00060.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10635150390235520"},{"key":"e_1_2_6_9_1","first-page":"632","article-title":"Background study of HIV\u20101 drug resistant mutations in treatment\u2010naive patients in liaoning province","volume":"28","author":"Han XX","year":"2006","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"e_1_2_6_10_1","first-page":"1041","article-title":"Sources of data for improved surveillance of HIV\/AIDS in China","volume":"38","author":"Jia Y","year":"2007","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_2_6_11_1","first-page":"356","article-title":"Molecular epidemiology of HIV\u20101 subtypes in southern China","volume":"38","author":"Laeyendecker O","year":"2005","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2010.0026"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2011.05.017"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2005.19.49"},{"key":"e_1_2_6_15_1","first-page":"263","article-title":"Prevalence of HIV infection and predictors for syphilis infection among female sex workers in southern China","volume":"40","author":"Lu F","year":"2009","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_2_6_16_1","first-page":"111","article-title":"Qualitative study of drug\u2010using and sexual behaviors of drug users in Guangxi","volume":"23","author":"Ming Z","year":"2002","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.23.11286-11295.2000"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msn083"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1019848026130"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000218881.01437.99"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328011e691"},{"key":"e_1_2_6_22_1","unstructured":"State Council AIDS Working Committee Office.UN Theme Group on AIDS in China. 2008. 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