{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:52:22Z","timestamp":1759009942806},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T00:00:00Z","timestamp":1344988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Whether resistant hepatitis B virus (HBV) strains are transmissible and can lead to chronic infection remains to be studied. The aim of this study was to investigate the clinical characteristics of patients with acute hepatitis B caused by lamivudine (LAM)\u2010resistant strains. Sera were collected from 234 Chinese patients with acute hepatitis B. LAM\u2010resistance mutations were identified by direct polymerase chain reaction (PCR) sequencing. LAM\u2010resistant HBV variants were detected in 11 of the 234 (4.7%) patients. Among these patients, six harbored the rtM204I mutation, two harbored the rtL180M\u2009+\u2009rtM204I mutations, one harbored the rtM204I\u2009+\u2009rtM204V mutations, one harbored the rtL80I\u2009+\u2009rtM204I mutations, and one harbored the rtV173L\u2009+\u2009rtL180M\u2009+\u2009rtM204V mutations. Three patients were infected with genotype B HBV and eight patients were infected with genotype C HBV. Two patients infected with viruses with LAM\u2010resistance mutations developed severe acute hepatitis. One patient developed chronic hepatitis B. This patient was infected with genotype C HBV that had LAM\u2010resistance mutations (rtL180M\u2009+\u2009rtM204I). The patient was diagnosed with an occult hepatitis B virus infection based on the presence of HBV DNA in the liver and the absence of detectable hepatitis B surface antigen (HBsAg) in the serum. LAM\u2010resistant HBV strains in China are transmissible, can cause acute hepatitis B, and can even progress to chronic infection in China. J. Med. Virol. 84:1558\u20131561, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23369","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T17:06:44Z","timestamp":1346173604000},"page":"1558-1561","source":"Crossref","is-referenced-by-count":6,"title":["Clinical characteristics and chronicity of acute hepatitis B induced by lamivudine\u2010resistant strains"],"prefix":"10.1002","volume":"84","author":[{"given":"Qingzhou","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yandan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiliang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270628"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80134-8"},{"key":"e_1_2_5_4_1","first-page":"324","article-title":"Chinese Society of Hepatology. 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