{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:41:52Z","timestamp":1768322512968,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The molecular epidemiology of HIV\u20101 in Brazil is complex and heterogeneous because several subtypes co\u2010circulate with some important regional differences. This study evaluated HIV\u20101 subtypes amongst pregnant women living in the metropolitan area and in the interior cities from central western Brazil. From June 2008 to June 2010, 86.9% of confirmed cases of HIV\u20101 infection amongst pregnant women (172 out of 198 cases) were recruited in Goiania\/Goias state. The HIV\u20101 <jats:italic>pol<\/jats:italic> gene was sequenced after nested\u2010PCR. HIV\u20101 subtypes were assigned by REGA, phylogenetic, and bootscan analyses. The median age of participants was 26 years (15\u201341 years range); 58.7% of participants were diagnosed during prenatal care and 51.7% of participants came from &gt;50 interior cities within Goias state. Amongst the 131 HIV\u20101 <jats:italic>pol<\/jats:italic> sequences, 64.9% were subtype B, 13.0% were BF1 recombinant, 11.4% were subtype C, 7.6% were subtype F1, and 2.3% were BC recombinant. According to the HIV\u20101 diagnosis date (1994\u20132010), a significant increase in subtype C and a decrease of BF1 mosaics were observed over time. All subtype C patients lived in interior cities where the highest prevalence of subtype C outside southern Brazil was observed (18.4%). Phylogenetic analysis revealed multiple independent introductions of the Brazilian subtype C clade from the southern\/southeastern regions of Brazil. The HIV\u20101 epidemic in women from central western Brazil infected by the heterosexual route is characterized by an unexpectedly high prevalence of subtype C viruses highly related to those circulating in southern\/southeastern Brazil. These findings highlight the importance of molecular surveillance programs outside large metropolitan regions in Brazil. J. Med. Virol. 85:396\u2013404, 2013.  \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23474","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T19:41:15Z","timestamp":1353526875000},"page":"396-404","source":"Crossref","is-referenced-by-count":12,"title":["Increasing heterosexual transmission of HIV\u20101 subtype C in Inland Central Western Brazil"],"prefix":"10.1002","volume":"85","author":[{"given":"Keila Correia","family":"Alc\u00e2ntara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica Nogueira Guarda","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludimila Paula Vaz","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Bello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariane Martins Ara\u00fajo","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02051-08"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.01.011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2009.03.016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10635150600755453"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328315e0aa"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035649"},{"key":"e_1_2_6_8_1","unstructured":"Brazil Brazilian Institute of Geography and Statistic. 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