{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T14:42:22Z","timestamp":1782225742495,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis B virus (HBV) infection is associated with increased expression of microRNA\u2010122. Serum microRNA\u2010122 and microRNA\u201022 levels were analyzed in 198 patients with chronic HBV who underwent liver biopsy and were compared with quantitative measurements of HBsAg, HBeAg, HBV DNA, and other clinical and histological findings. Levels of serum microRNA\u2010122 and microRNA\u201022 were determined by reverse transcription\u2010TaqMan PCR. Serum levels of microRNA\u2010122 and microRNA\u201022 were correlated (R<jats:sup>2<\/jats:sup>\u2009=\u20090.576; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and both were elevated in chronic HBV patients. Significant linear correlations were found between microRNA\u2010122 or microRNA\u201022 and HBsAg levels (R<jats:sup>2<\/jats:sup>\u2009=\u20090.824, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 and R<jats:sup>2<\/jats:sup>\u2009=\u20090.394, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, respectively) and ALT levels (R<jats:sup>2<\/jats:sup>\u2009=\u20090.498, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 and R<jats:sup>2<\/jats:sup>\u2009=\u20090.528, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, respectively). MicroRNA\u2010122 levels were also correlated with HBV DNA titers (R<jats:sup>2<\/jats:sup>\u2009=\u20090.694, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 and R<jats:sup>2<\/jats:sup>\u2009=\u20090.421, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Levels of these microRNAs were significantly higher in HBeAg\u2010positive patients compared to HBeAg\u2010negative patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). MicroRNA\u2010122 levels were also lower in patients with advanced liver fibrosis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and lower inflammatory activity (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.025). These results suggest that serum micro\u2010RNA levels are significantly associated with multiple aspects of HBV infection. The biological meaning of the correlation between microRNA\u2010122 and HBsAg and should be investigated further. J. Med. Virol. 85:789\u2013798, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmv.23540","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T14:56:51Z","timestamp":1363618611000},"page":"789-798","source":"Crossref","is-referenced-by-count":62,"title":["Circulating microRNA\u201022 correlates with microRNA\u2010122 and represents viral replication and liver injury in patients with chronic hepatitis B"],"prefix":"10.1002","volume":"85","author":[{"given":"Keiko","family":"Arataki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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