{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:13:12Z","timestamp":1784038392510,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T00:00:00Z","timestamp":1371081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The significance of human rhinoviruses (HRV) as prevailing respiratory pathogens has sharpened during the recent years followed by implementation of molecular methods in detection. Rhinoviruses are detected exceedingly in hospitalized cases of respiratory infection with varying severity, in addition to being frequent in cases of common cold. The aim of this study was to evaluate occurrence of HRV in a prospective study material. The prospective INDIS material comprises nasopharyngeal (N\u2009=\u2009429) and fecal (N\u2009=\u2009425) specimens from children under 11 years of age collected during any clinical infection. Validated real\u2010time RT\u2010PCR assays were applied for the detection of HRV. HRV were detected numerously not only in the nasopharyngeal specimens, but a myriad also in fecal specimens, 236 (55.0%) and 149 (35.1%), respectively, fecal findings actually beyond anticipation. A total of 13 of HRV\u2010positive fecal specimens were selected for genetic typing in the VP4\/VP2 coding region. HRV\u2010A strains were detected in seven specimens: HRV\u2010A9, \u2010A10, \u2010A24, \u2010A49, \u2010A56 and \u2010A82. HRV\u2010B\u2014strains were detected three times: HRV\u2010B42 and \u2010B79, and HRV\u2010C twice: HRV\u2010C12 and HRV\u2010Cpat4. HRV\u2010B42 also showed cytopathic effect in cell culture, confirmed by real\u2010time RT\u2010PCR and VP4\/VP2 sequencing, suggesting presence of viable HRV in fecal specimens. <jats:bold><jats:italic>J. Med. Virol. 85:1466\u20131472, 2013<\/jats:italic><\/jats:bold>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23593","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T19:27:48Z","timestamp":1371151668000},"page":"1466-1472","source":"Crossref","is-referenced-by-count":12,"title":["Human rhinoviruses in INDIS\u2010study material\u2014evidence for recovery of viable rhinovirus from fecal specimens"],"prefix":"10.1002","volume":"85","author":[{"given":"Carita","family":"Savolainen\u2010Kopra","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Surveillance and Control, Virology Unit National Institute for Health and Welfare (THL) Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja\u2010Leena","family":"Simonen\u2010Tikka","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Surveillance and Control, Virology Unit National Institute for 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