{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:09:47Z","timestamp":1768262987239,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T00:00:00Z","timestamp":1371081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Infection by high\u2010risk types of human papillomavirus (HPV) is considered necessary but not sufficient for the development of cervical cancer. Previous studies suggested that cytomegalovirus (CMV) and Epstein\u2010barr virus (EBV) could be co\u2010factors of HPV\u2010associated carcinogenesis. The aim of this study was to characterize the prevalence of CMV and EBV and evaluate its association with the development cervical lesions in Portugal. The prevalence of CMV and EBV infections was determined by real\u2010time PCR in 89 cervical samples from women with different histological lesions, who attended the Portuguese Institute of Oncology of Porto. This study revealed an overall prevalence of 4.5% for CMV and 10.1% for EBV. Age\u2010stratified analysis revealed that CMV infection was present in individuals &lt;30 and &gt;60 years old, while EBV infection was present in all age groups. CMV was detected in 9.5% of low\u2010grade lesions and in 22.2% of in situ\/invasive carcinomas, while EBV infection was found in all different types of lesions. In addition, data revealed that CMV infection was associated with an increased risk of in situ\/invasive carcinoma development (OR\u2009=\u20091.28; <jats:italic>P<\/jats:italic>\u2009=\u20090.035). The study reveals a low prevalence for both viruses; nevertheless, these results are important for knowledge on the shedding of EBV and CMV in cervical samples. <jats:bold><jats:italic>J. Med. Virol. 85:1409\u20131413, 2013<\/jats:italic><\/jats:bold>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23596","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T19:27:48Z","timestamp":1371151668000},"page":"1409-1413","source":"Crossref","is-referenced-by-count":13,"title":["Characterization of cytomegalovirus and epstein\u2010barr virus infection in cervical lesions in Portugal"],"prefix":"10.1002","volume":"85","author":[{"given":"Joana","family":"Marinho\u2010Dias","sequence":"first","affiliation":[{"name":"Virology Service Portuguese Institute of Oncology of Porto Porto Portugal"},{"name":"Superior School of Biotechnology (Universidade Cat\u00f3lica Portuguesa) Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Virology Service Portuguese Institute of Oncology of Porto Porto Portugal"},{"name":"Portuguese 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