{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:42:50Z","timestamp":1782996170146,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T00:00:00Z","timestamp":1369180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Acute hepatitis due to hepatitis E virus (HEV) is endemic in Bangladesh, but its epidemiological characteristics and virological features remain obscure. An outbreak of acute icteric hepatitis E occurred in Rajshahi, Bangladesh during 2010 when 200 patients with visible jaundice visited physicians within a period of 1 month (January\u2013February). Clinical and epidemiological data were collected from these patients using questionnaires. Nucleic acids were isolated from 15 patients who were selected at random to ascertain their HEV genotypes. Near\u2010complete nucleotide sequences of the HEV genome were detected in two patients and partial ORF2 regions in the other 13 patients. All patients tested positive for IgM antibodies to HEV but negative for other hepatitis viruses. Most patients were icteric and complained of vomiting, fever, itching, and abdominal pain. All 15 HEV sequences formed a single cluster within genotype 1a. Two of the 7,186\u2010nt HEV sequences were 99.8% identical. This is the first study to report the clinical, epidemiological, and molecular characterization of an outbreak of acute hepatitis E in Bangladesh. <jats:bold><jats:italic>J. Med. Virol. 85:1369\u20131376, 2013<\/jats:italic><\/jats:bold>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23601","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T21:20:58Z","timestamp":1369257658000},"page":"1369-1376","source":"Crossref","is-referenced-by-count":27,"title":["Epidemiological and molecular analyses of a non\u2010seasonal outbreak of acute icteric hepatitis E in Bangladesh"],"prefix":"10.1002","volume":"85","author":[{"given":"Mohammad","family":"Harun\u2010Or\u2010Rashid","sequence":"first","affiliation":[{"name":"Department of Hepatology Rajshahi Medical College Rajshahi Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheikh Mohammad Fazle","family":"Akbar","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Toshiba General Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Toshiba General Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamun","family":"Al\u2010Mahtab","sequence":"additional","affiliation":[{"name":"Department of Hepatology Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Sakirul Islam","family":"Khan","sequence":"additional","affiliation":[{"name":"Bangladesh Agricultural University Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Abdul","family":"Alim","sequence":"additional","affiliation":[{"name":"Department of Hepatology Rajshahi Medical College Rajshahi Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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