{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:31:21Z","timestamp":1758709881659},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T00:00:00Z","timestamp":1373587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>Swabbing the surface of a genital lesion to obtain a sample for HPV DNA testing is less invasive than a biopsy, but may not represent HPV types present in the lesion tissue. The objective of this study was to examine the concordance of HPV types detected in swab and biopsy samples from 165 genital lesions from men ages 18\u201370. Lesions included 90 condyloma, 10 penile intraepithelial neoplasia (PeIN), 23 non\u2010condyloma with a known histology, and 42 lesions with an undetermined histology. All lesions were sampled by swabbing the surface of the lesion with a pre\u2010wetted Dacron swab and taking a shave biopsy. HPV genotyping was performed using Linear Array for swab samples and INNO\u2010LiPA for biopsy samples. The kappa and McNemar statistics were used to compare the concordance of detecting HPV types in swab and biopsy samples. Both sampling methods had high agreement for detection of HPV DNA in condyloma (87.8% agreement) and PeIN (100% agreement). There was also high concordance for detection of HPV16 (kappa\u2009=\u20091.00) and HPV18 (kappa\u2009=\u20091.00) in PeIN, however, agreement was low to moderate for detecting HPV6 (kappa\u2009=\u20090.31) and HPV11 (kappa\u2009=\u20090.56) in condyloma. Low to moderate agreement was also observed between sampling methods for detecting individual HPV types in the non\u2010condyloma and lesions with an indefinite histology. The results suggest that obtaining a biopsy in addition to swabbing the surface of a lesion may provide additional information about specific HVP types associated with male genital lesions. <jats:bold><jats:italic>J. Med. Virol. 85:1561\u20131566, 2013<\/jats:italic><\/jats:bold>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23635","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T15:23:00Z","timestamp":1373642580000},"page":"1561-1566","source":"Crossref","is-referenced-by-count":16,"title":["Concordance of human papillomavirus types detected on the surface and in the tissue of genital lesions in men"],"prefix":"10.1002","volume":"85","author":[{"given":"Gabriella M.","family":"Anic","sequence":"first","affiliation":[{"name":"Department of Cancer Epidemiology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane L.","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology University of South Florida Morsani College of Medicine Tampa Florida"},{"name":"Cutaneous Oncology Program Moffitt Cancer Center Tampa 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University of S\u00e3o Paulo and School of Medicine of Santa Casa de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Lazcano\u2010Ponce","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Salud P\u00fablica Cuernavaca M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Gage","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Jose C.","family":"Silva","sequence":"additional","affiliation":[{"name":"Centro de Referencia e Treinamento em DST\/AIDS S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L.","family":"Baggio","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research S\u00e3o Paulo 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