{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:23:03Z","timestamp":1778127783814,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T00:00:00Z","timestamp":1377561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Viral infections have been associated with autoimmune connective tissue diseases. To evaluate whether active infection by Epstein\u2013Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus (HHV)\u20106, \u20107, \u20108, as well as parvovirus B19 (B19V) occur in patients with autoimmune connective tissue diseases, viral DNA loads were assessed in paired samples of serum and peripheral blood mononuclear cells (PBMCs) of 115 patients affected by different disorders, including systemic sclerosis, systemic, and discoid lupus erythematosus, rheumatoid arthritis, and dermatomyositis. Two additional groups, patients affected by inflammatory diseases (n\u2009=\u200951) and healthy subjects (n\u2009=\u200958) were studied as controls. The titers of anti\u2010HHV\u20106 and anti\u2010EBV antibodies were also evaluated. Cell\u2010free HHV\u20106 serum viremia was detected in a significantly higher proportion of connective tissue diseases patients compared to controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0002); a significant association between HHV\u20106 reactivation and the active disease state was found only for lupus erythematosus (<jats:italic>P<\/jats:italic>\u2009=\u20090.021). By contrast, the rate of cell\u2010free EBV viremia was similar in patients and controls groups. Cell\u2010free CMV, HHV\u20108, and B19V viremia was not detected in any subject. Anti\u2010HHV\u20106 and anti\u2010EBV early antigen IgG titers were both significantly higher in autoimmune diseases patients as compared to healthy controls, although they were not associated with the presence of viremia. EBV, HHV\u20106, \u20107 prevalence and viral load in PBMCs of patients with connective tissue diseases and controls were similar. These data suggest that HHV\u20106 may act as a pathogenic factor predisposing patients to the development of autoimmune connective tissue diseases or, conversely, that these disorders may predispose patients to HHV\u20106 reactivation. <jats:bold><jats:italic>J Med. Virol. 85:1925\u20131934, 2013<\/jats:italic>.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23670","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T19:42:01Z","timestamp":1377632521000},"page":"1925-1934","source":"Crossref","is-referenced-by-count":60,"title":["Selective reactivation of human herpesvirus 6 in patients with autoimmune connective tissue diseases"],"prefix":"10.1002","volume":"85","author":[{"given":"Francesco","family":"Broccolo","sequence":"first","affiliation":[{"name":"Department of Health Sciences University of Milano\u2010Bicocca Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Drago","sequence":"additional","affiliation":[{"name":"Di.S.E.M, Department of Endocrinologic and Metabolic Sciences, Section of Dermatology University of Genoa Genova 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