{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:19Z","timestamp":1786978099517,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T00:00:00Z","timestamp":1373587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      This study reports a previously healthy, immunocompetent adult male in whom human herpesvirus 7 (HHV\u20107) DNA was detected continuously from the cerebrospinal fluid (CSF). This patient developed definite sarcoidosis with primary symptomatic manifestations in the central nervous system (CNS). The initial presentation was with loss of visual acuity and papilledema. Brain MR imaging at presentation confirmed papilledema, but otherwise there were no focal abnormalities or signs of hydrocephalus. CSF investigation revealed pleocytosis and elevated protein levels. HHV\u20107 DNA was detected repeatedly from CSF but not from blood over 1 year follow\u2010up. High resolution computed tomography of lungs was normal. Positron emission tomography showed several metabolically active lymph nodes in the mediastinum, and the histopathological investigation revealed granulomatous inflammation consistent with sarcoidosis. The finding of HHV\u20107 DNA in the CSF in the context of neurosarcoidosis has not been reported previously. The detection of HHV\u20107 DNA may result from the selective activation of CD4+ T\u2010lymphocytes in the CSF caused by neurosarcoidosis. Further studies are needed to establish whether the detection of HHV\u20107 DNA in the CSF in association with neurosarcoidosis represents a clinically significant HHV\u20107 CNS infection.\n                      <jats:bold>\n                        <jats:italic>J Med. Virol. 85:1935\u20131939, 2013<\/jats:italic>\n                        .\n                      <\/jats:bold>\n                      \u00a9 2013 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.23683","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T12:07:47Z","timestamp":1373630867000},"page":"1935-1939","source":"Crossref","is-referenced-by-count":9,"title":["Detection of human herpesvirus 7 DNA from the CSF in association with neurosarcoidosis"],"prefix":"10.1002","volume":"85","author":[{"given":"Mika H.","family":"Martikainen","sequence":"first","affiliation":[{"name":"Division of Clinical Neurosciences University of Turku and Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha O.","family":"Gr\u00f6nroos","sequence":"additional","affiliation":[{"name":"Department of Virology University of Turku Turku 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