{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:40:24Z","timestamp":1696398024821},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T00:00:00Z","timestamp":1376870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>The prevalence of hepatitis C virus (HCV) genotypes depends on geographical location. HCV genotyping is important for epidemiological investigations and treatment management. The aim of this study was to determine the HCV genotype prevalence in the most prominent risk groups in the Republic of Macedonia in the last 5 years and to evaluate its association with patient's age, gender, and mode of transmission. A total of 1,167 HCV positive patients, divided into three risk groups (intravenous drug use, chronic hemodialysis, and other risk factor), were genotyped using an in\u2010house ASO hybridization method with genotype\u2010specific oligonucleotide probes. The genotypes 1, 2, and 3 were present with 52.2%, 0.6%, and 47.0%, respectively. Genotype 1 was most prevalent in hemodialysis (89.0%) and other risk factor group (53.8%). It was found associated independently with hemodialysis, age &gt;40 and female gender. Genotype 3 predominated in intravenous drug users (64.0%) and was associated significantly also with age \u226440 and male gender. Multivariable logistic regression analysis pointed out hemodialysis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, Exp (B)\u2009=\u200912.0) as a positive predictor factor for genotype 1 and age \u226440 (<jats:italic>P<\/jats:italic>\u2009=\u20090.021, Exp (B)\u2009=\u20091.8) and intravenous drug use (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, Exp (B)\u2009=\u20098.4) as a positive predictor factors for genotype 3. In conclusion, the main transmission route of HCV infection in the Republic of Macedonia is intravenous drug use, followed by hemodialysis. HCV genotypes 1 and 3 dominate in these two most prominent risk groups in the Republic of Macedonia. <jats:bold><jats:italic>J. Med. Virol. 85:2072\u20132078, 2013<\/jats:italic>.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23706","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T22:01:40Z","timestamp":1376949700000},"page":"2072-2078","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of hepatitis C virus genotypes in risk groups in the Republic of Macedonia: A 5 years survey"],"prefix":"10.1002","volume":"85","author":[{"given":"Sanja","family":"Kiprijanovska","sequence":"first","affiliation":[{"name":"Research Center for Genetic Engineering and Biotechnology \u201cGeorgi D. Efremov\u201d Macedonian Academy of Sciences and Arts Skopje Republic of Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Davalieva","sequence":"additional","affiliation":[{"name":"Research Center for Genetic Engineering and Biotechnology \u201cGeorgi D. 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