{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:05:17Z","timestamp":1763726717622,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T00:00:00Z","timestamp":1376870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science KAKENHI","doi-asserted-by":"crossref","award":["23592406","24791712","22591827"],"award-info":[{"award-number":["23592406","24791712","22591827"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The aim of this study was to investigate the relationship between viral load in single human papillomavirus (HPV) 16 or 52 persistent infection and the progression of later cytopathological findings in the uterine cervix. Cervical cytology and HPV genotyping tests were repeated within 3\u20136 months in 305 women with oncogenic HPV. Twenty\u2010four cases of single HPV 52 persistent infection and 24 cases of single HPV 16 persistent infection were identified. Cases with later cytopathological findings showing progression were defined as the progression group, while those with no change or regression were the non\u2010progression group. Relative HPV DNA loads were determined by quantitative real\u2010time polymerase chain reaction and expressed relative to human albumin (<jats:italic>ALB<\/jats:italic>) DNA. Differences between the two groups were evaluated. The median relative HPV 52 DNA load was 2.211 in the progression group and 0.022 in the non\u2010progression group (Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test, <jats:italic>P<\/jats:italic>\u2009=\u20090.003). The median relative HPV 16 DNA load was 4.206 in the progression group and 0.103 in the non\u2010progression group (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). HPV 52 and 16 DNA loads assessed by quantitative real\u2010time methods may be useful short\u2010term markers for identifying women at high risk for progression of cervical cytological pathology. <jats:bold><jats:italic>J. Med. Virol. 85:2093\u20132100, 2013<\/jats:italic>.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23709","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T22:28:38Z","timestamp":1376951318000},"page":"2093-2100","source":"Crossref","is-referenced-by-count":2,"title":["Initial viral load in cases of single human papillomavirus 16 or 52 persistent infection is associated with progression of later cytopathological findings in the uterine cervix"],"prefix":"10.1002","volume":"85","author":[{"given":"Daisuke","family":"Hamaguchi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyonori","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagasaki University Graduate School of Biomedical 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