{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T18:18:50Z","timestamp":1773339530710,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T00:00:00Z","timestamp":1378339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>The case of an HIV\u2010positive patient who cleared formerly acute HBV infection and experienced HBV exacerbation before starting antiretroviral therapy (ART) followed by a severe elevation of liver enzymes one month after the introduction of ART is reported. Laboratory tests revealed the presence of a subgenotype A2 carrying at least seven different mutations within the S protein and high lopinavir plasma concentrations. Irrespectively of the many possible mechanisms of HBV reactivation in patients infected with HIV (escape mutants selection, host immune deficiency progression, antiretroviral\u2010related immune reconstitution, glucocorticosteroids, chemotherapy), the message is that HIV patients should be monitored strictly not only by serological and virological assays to recognize early HBV reactivation, but also for drug over\u2010exposure. <jats:bold><jats:italic>J. Med. Virol. 86:97\u2013101, 2014<\/jats:italic>.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23721","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T19:20:42Z","timestamp":1378408842000},"page":"97-101","source":"Crossref","is-referenced-by-count":10,"title":["Recurrence of another hepatitis B virus escape mutant comes back in a patient infected with HIV and low CD4+ count"],"prefix":"10.1002","volume":"86","author":[{"given":"Laura","family":"Milazzo","sequence":"first","affiliation":[{"name":"III Division of Infectious Diseases Luigi Sacco University Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Ebranati","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences \u2018L Sacco\u2019 Hospital, Section of Infectious Diseases and Immunopathology University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pharmacology Luigi Sacco University Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Gabanelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences \u2018L Sacco\u2019 Hospital, Section of Infectious Diseases and Immunopathology University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences \u2018L Sacco\u2019 Hospital, Section of Infectious Diseases and Immunopathology University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianguglielmo","family":"Zehender","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences \u2018L Sacco\u2019 Hospital, Section of Infectious Diseases and Immunopathology University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Gervasoni","sequence":"additional","affiliation":[{"name":"III Division of Infectious Diseases Luigi Sacco University Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,5]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91874-A"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.11.024"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1258\/095646206775220612"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-310"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.03.015"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/108729103322395465"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200308150-00007"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/592987"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1619"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/317535"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis268"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki314"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/381444"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-198812000-00006"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06353-11"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2000.0720"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.23721","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.23721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:19:14Z","timestamp":1696400354000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.23721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,5]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1002\/jmv.23721"],"URL":"https:\/\/doi.org\/10.1002\/jmv.23721","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,5]]}}}