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The analysis of the LMP1 alleles collected revealed that they practically matched previously described LMP1 variants; however, some characteristic features were also detected. In particular, the G212S substitution in LMP1 isolates investigated was not observed at all. Tumor samples obtained from nasopharyngeal carcinoma and other tumors of the oral cavity did not differ significantly either in the frequency of \u201chigh oncogenic\u201d LMP1 alleles with 10 aa and\/or 23 aa deletions (LMP1<jats:sup>China1<\/jats:sup> and\/or LMP1<jats:sup>Med+<\/jats:sup>), nor in the number of 11 aa repeats and the frequency of 5 aa motif insertions. No differences in the frequency of amino acid substitutions between LMP1 alleles obtained from tumor and throat washing samples of both patient groups were also detected. The data obtained may indicate that in both nasopharyngeal carcinoma patients and patients with other tumors of the oral cavity, the EBV strains with similar LMP1 variants are found to persist. This observation allows us to suggest that in non\u2010endemic areas, EBV strains with any LMP1 alleles can initiate the nasopharyngeal carcinoma development but only in those individuals who have a genetic predisposition to the disease and are subjected to specific environmental, and\/or dietary factors present in certain geographic areas. <jats:bold><jats:italic>J. Med. Virol. 86:290\u2013300, 2014<\/jats:italic>.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23729","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T19:18:58Z","timestamp":1378408738000},"page":"290-300","source":"Crossref","is-referenced-by-count":17,"title":["Epstein\u2013barr virus latent membrane protein 1 polymorphism in nasopharyngeal carcinoma and other oral cavity tumors in Russia"],"prefix":"10.1002","volume":"86","author":[{"given":"Natalia","family":"Senyuta","sequence":"first","affiliation":[{"name":"Laboratory of Viral Carcinogenicity N.N. Blokhin Cancer Research Center Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Yakovleva","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Carcinogenicity N.N. 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