{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:49:07Z","timestamp":1773287347853,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T00:00:00Z","timestamp":1379030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Russian Foundation for Basic Research"},{"name":"Government of the Sverdlovsk Region","award":["12-04-31263"],"award-info":[{"award-number":["12-04-31263"]}]},{"name":"Government of the Sverdlovsk Region","award":["13-04-96045"],"award-info":[{"award-number":["13-04-96045"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Tick\u2010borne encephalitis (TBE) is a natural focal viral neuroinfection that is widespread in the temperate zone of Eurasia. Knowledge of the genetic structure of tick\u2010borne encephalitis virus (TBEV) populations is important for understanding, not only the origin and evolution of the virus, but also the formation and maintenance of natural foci. A new approach to the differentiation of TBEV strains within subtype, with clusterons as the basis of analysis, has recently been proposed. In the present study, the genetic structure of TBEV\u2010Sib populations has been investigated based on 387 strains isolated in the Middle Urals (Sverdlovsk region). Fourteen of the 18 currently known TBEV\u2010Sib clusterons were identified. They belong to the Asian and Eastern European (Baltic) groups. It was shown that each TBE foci could be characterized by a unique clusteron profile. Three clusterons that emerged within the last 50 years have been identified which implies an active evolutionary process in the TBEV\u2010Sib populations. The greatest diversity of clusterons was observed in the south of the Middle Urals along the Trans\u2010Siberian Way. Such a pattern could reflect the history of colonization of the area and is closely related to the roads passing from Siberia to the European part of Russia through the Urals. In this article, the principles of continuous monitoring in the regional and local TBE foci are proposed, based on the quantitative and qualitative analysis of TBEV\u2010Sib clusteron profiles. <jats:bold><jats:italic>J. Med. Virol. 86:283\u2013289, 2014<\/jats:italic>.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23732","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T19:42:41Z","timestamp":1379101361000},"page":"283-289","source":"Crossref","is-referenced-by-count":12,"title":["Clusterons as a tool for monitoring populations of tick\u2010borne encephalitis virus"],"prefix":"10.1002","volume":"86","author":[{"given":"Sergey Y.","family":"Kovalev","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Genetics, Department of Biology Ural Federal University Yekaterinburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana A.","family":"Mukhacheva","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics, Department of Biology Ural Federal University Yekaterinburg 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