{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:44:51Z","timestamp":1788050691782,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T00:00:00Z","timestamp":1381881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Cytomegalovirus (CMV), human herpesvirus 6 (HHV\u20106) and 7 (HHV\u20107) are important pathogens in immunocompromised patients. To elucidate the kinetics of the three \u03b2\u2010herpesviruses in saliva and urine samples were collected serially from children with renal diseases. Twenty children with renal diseases were enrolled in this study. A total of 240 saliva and urine samples were collected monthly from the patients over a 1\u2010year period. Viral DNAs loads were measured by real\u2010time PCR. In 10 CMV seropositive patients CMV DNA was detected rarely in saliva and CMV DNA load was lower than the other two \u03b2\u2010herpesviruses DNA loads. All patients were seropositive for HHV\u20106B and the virus was detected frequently in saliva. Two of 20 patients were HHV\u20107 seronegative. High copies of viral DNA were detected continuously in saliva of the HHV\u20107 seropositive patients. Although neither CMV nor HHV\u20106B DNA load was different among the three renal diseases, HHV\u20107 DNA load was different among the diseases (<jats:italic>P<\/jats:italic>\u2009=\u20090.039). HHV\u20106B DNA loads were significantly higher in patients with immunosuppressive treatment compared to those without treatment (<jats:italic>P<\/jats:italic>\u2009=\u20090.013). Although CMV DNA was detected in urine samples collected from 5 of 10 CMV seropositive patients, HHV\u20106B and HHV\u20107 DNA were detected at relatively low frequencies in urine. No remarkable temporal associations between viral DNA excretion and proteinuria or immunosuppressive treatment were demonstrated. The pattern of viral DNA excretion in saliva and urine were different among the three viruses. No temporal correlation was observed between viral infection and renal diseases. <jats:bold><jats:italic>J. Med. Virol. 86:505\u2013511, 2014<\/jats:italic>.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23782","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T14:36:52Z","timestamp":1381934212000},"page":"505-511","source":"Crossref","is-referenced-by-count":17,"title":["Analysis of the shedding of three \u03b2\u2010herpesviruses in urine and saliva of children with renal disease"],"prefix":"10.1002","volume":"86","author":[{"given":"Yasuto","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Pediatrics Fujita Health University School of Medicine Toyoake Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Morooka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fujita Health University School of Medicine Toyoake Aichi 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