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Here, 224 pools of 80 HIV\u2010negative samples (N\u2009=\u200917,920) were screened for viral RNA from HCV, GBV\u2010C, and influenza A. No evidence of influenza A was found, but HCV and GBV\u2010C were common (1.2% and 1.7% prevalence, respectively), demonstrating the utility of pooled testing in locating individuals that may remain undiagnosed otherwise. By sequencing positive pools, potential transmission clusters may be located as well. <jats:bold><jats:italic>J. Med. 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