{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:27:31Z","timestamp":1789590451596,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T00:00:00Z","timestamp":1388966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Human rhinovirus (HRV) is a causative agent of acute respiratory tract infections. This study analyzed the prevalence and clinical characteristics of three HRV groups (HRV\u2010A, \u2010B, and \u2010C) among 1,165 children aged 14 years or younger who were hospitalized with acute lower respiratory tract infection in China. PCR or reverse transcription\u2010PCR was performed to detect 14 respiratory viruses in nasopharyngeal aspirates collected from September 2007 to August 2008 in Changsha, China. HRV was detected in 202 (17.3%) of the 1,165 children; 25.3% of the HRV\u2010positive children were 13\u201336 months of age (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u200922.803, <jats:italic>P<\/jats:italic>\u2009=\u20090.000). HRV was detected year round and peaked between September and December. Fifty\u2010three percent of the HRV\u2010positive samples were also positive for other respiratory viruses; respiratory syncytial virus (RSV) was the most common secondary virus. Phylogenetic analysis using the VP4\/VP2 region grouped the HRV\u2010positive strains as follows: 101 HRV\u2010A (50.0%), 21 HRV\u2010B (10.4%), and 80 HRV\u2010C (39.6%). HRV\u2010A infections occurred predominantly in spring and autumn, and the peak prevalence of HRV\u2010C was in early winter and late autumn. HRV\u2010B infections were less common in spring (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u200931.914, <jats:italic>P<\/jats:italic>\u2009=\u20090.000). No significant difference in clinical severity or presentation was found between patients with HRV single infection and HRV co\u2010detections. Furthermore, the clinical characterizations did not differ among the three HRV species. These results suggest that HRV\u2010C is an important viral agent along with HRV\u2010A and HRV\u2010B and that among hospitalized children with acute lower respiratory tract infection in China, the three HRV genotypes have similar clinical characteristics. <jats:bold><jats:italic>J. Med. Virol. 86:1983\u20131989, 2014<\/jats:italic>.<\/jats:bold> \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23861","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T07:40:42Z","timestamp":1388994042000},"page":"1983-1989","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence of human rhinovirus in children admitted to hospital with acute lower respiratory tract infections in Changsha, China"],"prefix":"10.1002","volume":"86","author":[{"given":"Sai\u2010Zhen","family":"Zeng","sequence":"first","affiliation":[{"name":"The People's Hospital of Hunan Province Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni\u2010Guang","family":"Xiao","sequence":"additional","affiliation":[{"name":"The People's Hospital of Hunan Province Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Ping","family":"Xie","sequence":"additional","affiliation":[{"name":"National Institute for Viral Disease Control and Prevention China CDC Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Cheng","family":"Xie","sequence":"additional","affiliation":[{"name":"National Institute for Viral Disease Control and Prevention China CDC Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Li","family":"Zhong","sequence":"additional","affiliation":[{"name":"The People's Hospital of Hunan Province Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"The People's Hospital of Hunan Province Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Huang","sequence":"additional","affiliation":[{"name":"The People's Hospital of Hunan Province Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[{"name":"The People's Hospital of Hunan Province Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010Jun","family":"Duan","sequence":"additional","affiliation":[{"name":"National Institute for Viral Disease Control and Prevention China CDC Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504666102"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/426869"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2005.01.020"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092410"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/1509.090493"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181d7a708"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017780"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.3.9117003"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-009-0383-z"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1128\/jcm.31.7.1886-1891.1993","article-title":"Detection of adenovirus in clinical specimens by polymerase chain reaction and liquid\u2010phase hybridization quantitated by time\u2010resolved fluorometry","volume":"31","author":"Hierholzer JC","year":"1993","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir634"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200802-309OC"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00745-09"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.09.025"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1411.080386"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01254-07"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/605697"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.06.042"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.09.033"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.05.009"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.03.012"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.06.007"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.041"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0583"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23251"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.04.016"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.3.9801052"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31815b4935"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(02)00016-3"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16d19.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(01)00343-3"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1086\/500136"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00170-0"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.23861","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.23861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T13:35:26Z","timestamp":1696599326000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.23861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,6]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/jmv.23861"],"URL":"https:\/\/doi.org\/10.1002\/jmv.23861","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,6]]}}}