{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T10:19:13Z","timestamp":1705141153281},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T00:00:00Z","timestamp":1388361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"King Fahad Medical City, Riyadh, Saudi Arabia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:label \/><jats:p>Although subclinical persistent infections with the human polyomaviruses BKV and JCV are ubiquitous worldwide, these are known to vary in relation to diseases present and geographical location. DNAs from 220 cervical smears and 109 invasive cervical carcinomas obtained from HIV positive and HIV negative Kenyan women of known HPV status were analyzed by nested endpoint PCR for BKV and JCV. BKV\u2013JCV DNA was detected in 5\/105 (4.7%) of cervical smears and in 6\/37 (16%) of cervical carcinomas from women infected with HIV whereas 9\/115 (7.8%) of the cervical smears and 4\/72 (5.5%) of the carcinomas were positive in HIV negative women. Nested PCR showed that all 24 samples were positive for JCV and not BKV. JCV was not more prevalent in either HPV positive (<jats:italic>P<\/jats:italic>\u2009=\u20090.438) or HPV negative women (<jats:italic>P<\/jats:italic>\u2009=\u20090.392). However, 37% of carcinomas and smears which were positive for JCV were also positive for a \u201chigh\u2010risk\u201d oncogenic HPV. Comparison of the incidence of JCV in cervical smears and cervical carcinomas showed a \u223c3\u2010fold increase in samples from HIV positive women with cervical carcinoma (<jats:italic>P<\/jats:italic>\u2009=\u20090.025) whereas no significant difference was found between cervical smears and cervical carcinomas from HIV negative women (<jats:italic>P<\/jats:italic>\u2009=\u20090.553). These results suggest that JCV may combine with high\u2010risk HPV infection in women infected with HIV to influence the rate of progression to invasive cervical carcinoma. <jats:bold><jats:italic>J. Med. Virol. 86:672\u2013677, 2014<\/jats:italic>.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23868","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T09:55:55Z","timestamp":1388397355000},"page":"672-677","source":"Crossref","is-referenced-by-count":10,"title":["Increased prevalence of JC polyomavirus in cervical carcinomas from women infected with HIV"],"prefix":"10.1002","volume":"86","author":[{"given":"Bandar","family":"Alosaimi","sequence":"first","affiliation":[{"name":"Viral Oncology Laboratories University of Manchester Institute of Cancer Sciences Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne","family":"Hampson","sequence":"additional","affiliation":[{"name":"Viral Oncology Laboratories University of Manchester Institute of Cancer Sciences Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"He","sequence":"additional","affiliation":[{"name":"Viral Oncology Laboratories University of Manchester Institute of Cancer Sciences Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Innocent O.","family":"Maranga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Nairobi, Kenyatta National Hospital Nairobi Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony. 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