{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:53:35Z","timestamp":1761663215268},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T00:00:00Z","timestamp":1389312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Biotechnology (DBT), Government of India"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:label \/><jats:p>Response to antiviral therapy for hepatitis C virus (HCV) depends upon the genotype and host immune response. IL28b gene mutations have been shown to modulate host antiviral immune response against genotype 1. However, the predictive value of IL28b polymorphism in genotype 3 HCV patients is largely unknown. The association of IL28b polymorphism with virological response was studied in 356 patients with genotype 3 chronic HCV undergoing treatment with peg\u2010interferon and ribavirin and was compared with matched controls. IL28b genotyping followed by DNA sequencing was performed to identify the CC, CT, or TT genotypes. Two log reduction of HCV RNA at Day 7 (Quick Viral Response, QVR) and HCV RNA negativity at Day 28 (Rapid Viral Response, RVR) were analyzed with CC and non\u2010CC genotypes in addition to other predictors of response. The associations of alleles with the response patterns were predicted. Sustained viral response was seen in 250 (70.2%) patients and the IL28b genotype CC\/CT\/TT distribution was 61.1%; 30.5%; and 8.4%, respectively. The non\u2010CC genotypes were significantly higher in non\u2010responders when compared to responders (67.6% vs. 38.9%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Interestingly, the rapid viral response in responders was observed in 72.7% with the CC genotype and in 27.2% with the non\u2010CC genotype (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Multivariate analysis showed CC genotype as an independent factor predicting the sustained viral response in patients infected with HCV genotype 3. In conclusion, the IL28b CT\/TT genotype strongly correlates with treatment non\u2010response in patients infected with HCV genotype 3 and CC genotype of IL28b is associated with higher quick viral response. <jats:bold><jats:italic>J. Med. Virol. 86:707\u2013712, 2014<\/jats:italic>.<\/jats:bold> \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23876","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T17:50:56Z","timestamp":1389376256000},"page":"707-712","source":"Crossref","is-referenced-by-count":9,"title":["Interleukin\u201028b CC genotype predicts early treatment response and CT\/TT genotypes predicts non\u2010response in patients infected with HCV genotype 3"],"prefix":"10.1002","volume":"86","author":[{"given":"Abhishak Chander","family":"Gupta","sequence":"first","affiliation":[{"name":"Institute of Liver and Biliary Sciences New Delhi India"},{"name":"GB Pant Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirupma","family":"Trehanpati","sequence":"additional","affiliation":[{"name":"Institute of Liver and Biliary Sciences New Delhi India"},{"name":"GB Pant Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukriti","family":"Sukriti","sequence":"additional","affiliation":[{"name":"Institute of Liver and Biliary Sciences New Delhi India"},{"name":"GB Pant Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed","family":"Hissar","sequence":"additional","affiliation":[{"name":"Institute of Liver and Biliary Sciences New Delhi India"},{"name":"GB Pant Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandana","family":"Midha","sequence":"additional","affiliation":[{"name":"Dayanand Medical College Ludiana Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit","family":"Sood","sequence":"additional","affiliation":[{"name":"Dayanand Medical College Ludiana Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiv K.","family":"Sarin","sequence":"additional","affiliation":[{"name":"Institute of Liver and Biliary Sciences New Delhi India"},{"name":"GB Pant Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199803000-00009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2012.01621.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-013-0074-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80342-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2012.01637.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1799-z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04082"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.080077"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08309"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.6.3637"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20561"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21932"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.057182"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.07.013"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22253"},{"key":"e_1_2_6_17_1","first-page":"839","article-title":"Retreatment with peg\u2010interferon and ribavirin in patients with chronic hepatitis C virus genotype 2 or 3 infection with prior relapse. Scand","volume":"48","author":"Lagging M","year":"2013","journal-title":"J Gastroenterol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.09.052"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.02.009"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-296"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.11.003"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2011.07.024"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2521"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.056"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.9714"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01525.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02715.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni873"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066403"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i12.1770"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.447"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80093-2"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.449"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08463"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364090"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00947-08"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.23876","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.23876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:24:57Z","timestamp":1696602297000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.23876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,10]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/jmv.23876"],"URL":"https:\/\/doi.org\/10.1002\/jmv.23876","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,10]]}}}