{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:03:58Z","timestamp":1716509038221},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T00:00:00Z","timestamp":1391040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Chronic hepatitis C patients may require steroids due to other comorbidities. However, there is not enough information to consider steroids as beneficial or harmful drugs on natural history of chronic hepatitis C. The aim of the present study was to examine the effect of low\u2010dose prolonged therapy with corticosteroids with or without azathioprine on these study patients. A retrospective\u2013prospective observational study was established. Twenty\u2010eight patients with chronic hepatitis C and treated with corticosteroids at low\u2010dose (\u226430\u2009mg\/day) with or without azathioprine for more than 6 months were included. AST, ALT, HCV RNA, and liver fibrosis were determined, and results were compared with a control group of non\u2010treated chronic hepatitis C patients. The mean age was 47\u2009\u00b1\u200910 years. The male proportion was 43%. The mean dose of prednisone was 9\u2009\u00b1\u20095\u2009mg\/day (range: 2.5\u201330\u2009mg\/day). The mean treatment time was 76\u2009\u00b1\u200980 months (range: 7\u2013349 months). Thirty six percent received concomitant azathioprine. Transaminases decreased significantly only within the first 3 months of treatment, with non\u2010significant changes thereafter. Corticosteroids led to a non\u2010significant increase in HCV RNA. Knodell Histology Activity Index decreased (from 8.5\u2009\u00b1\u20093.7 to 4.7\u2009\u00b1\u20091.7;<jats:italic>P<\/jats:italic>\u2009=\u20090.1). Fibrosis progression per year (final fibrosis stage\u2014initial fibrosis stage\/time between explorations, in years), was lower in treated cases than in control group (0.054\u2009\u00b1\u20090.25\u2009units vs. 0.196\u2009\u00b1\u20090.6\u2009units,<jats:italic>P<\/jats:italic>\u2009=\u20090.26). In conclusion, corticosteroid treatment caused a significant initial decrease in transaminases, non\u2010significant changes in HCV RNA, and a trend to a slower fibrosis progression in comparison to a control group. Therefore, corticosteroids did not accelerate progression of chronic hepatitis C.<jats:bold><jats:italic>J. Med. Virol. 86:758\u2013764, 2014<\/jats:italic>.<\/jats:bold>\u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23889","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T12:36:48Z","timestamp":1391085408000},"page":"758-764","source":"Crossref","is-referenced-by-count":3,"title":["Does low\u2010dose prolonged steroid therapy affect the natural history of chronic hepatitis C?"],"prefix":"10.1002","volume":"86","author":[{"given":"Marta","family":"Romero Guti\u00e9rrez","sequence":"first","affiliation":[{"name":"Liver\u2010Gastroenterology Service Hospital Virgen de la Salud Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santos","family":"del Campo Terr\u00f3n","sequence":"additional","affiliation":[{"name":"Liver Gastroenterology Service Hospital Universitario Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Moreno Zamora","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Hospital Universitario Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jos\u00e9","family":"S\u00e1nchez Ruano","sequence":"additional","affiliation":[{"name":"Liver\u2010Gastroenterology Service Hospital Virgen de la Salud Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1s","family":"Artaza Varasa","sequence":"additional","affiliation":[{"name":"Liver\u2010Gastroenterology Service Hospital Virgen de la Salud Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"B\u00e1rcena Marug\u00e1n","sequence":"additional","affiliation":[{"name":"Liver Gastroenterology Service Hospital Universitario Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1965.03080070025007"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-66-5-924"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2005.00683.x"},{"key":"e_1_2_5_5_1","first-page":"CD002904","article-title":"Glucocorticosteroids for viral hepatitis C","author":"Brok J","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.008"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23425"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.11.008"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.02.004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0016-5085(83)90030-6","article-title":"Autoimmune features as determinants of prognosis in steroid\u2010treated chronic active hepatitis of uncertain etiology","volume":"85","author":"Czaja AJ","year":"1983","journal-title":"Gastroenterology"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(93)90089-B"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2004.06.009"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90077-9"},{"key":"e_1_2_5_14_1","first-page":"24","article-title":"Immunosuppressive therapy in chronic active hepatitis (CAH). 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