{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T07:10:55Z","timestamp":1724310655417},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:label \/><jats:p>The risk of cervical intraepithelial neoplasia and\/or invasive cervical cancer associated with untypable human papillomavirus (HPV) infections has been not investigated fully. HPV infection caused by 18 high\u2010risk and 7 low\u2010risk genotypes as detected by the INNO\u2010LIPA genotyping system, was investigated in 4,258 women with abnormal Pap smear referred to a colposcopic service. The prevalence of HPV infection was 76.1%. Rates of cervical intraepithelial neoplasia grade 3+ were 0.88% (9\/1,017) in HPV\u2010negative subjects, 1.8% (7\/380) in subjects with untypable HPV infection, 3.2% (11\/343) in subjects with single\/multiple low\u2010risk types, 28.3% (201\/709) in subjects with multiple low and high\u2010risk types, 15.2% (162\/1,069) in subjects with single high\u2010risk types, and 31.2% (229\/733) in those with multiple high\u2010risk types. Compared to women without any HPV infection, the odds ratios of cervical intraepithelial neoplasia grade 2+ or grade 3+ in subjects with untypable or low\u2010risk HPV genotypes were 5.73 (95% CI\u2009=\u20092.79\u201311.78) and 12.4 (95% CI\u2009=\u20096.31\u201324.5, <jats:italic>P<\/jats:italic>\u2009=\u20090.014 compared to untypable) and 3.1 (95% CI\u2009=\u20091.11\u20138.16) and 7.1 (95% CI\u2009=\u20092.9\u201317.2, <jats:italic>P<\/jats:italic>\u2009=\u20090.07 compared to untypable), respectively. In the subgroup of subjects with cervical intraepithelial neoplasia grade 1 or negative colposcopy\/biopsy, the progression to cervical intraepithelial neoplasia grade 2+ at follow\u2010up (median 25 months, range 6\u201370) was 2% (14\/684), 3.4% (7\/205), and 5.6% (11\/195, <jats:italic>P<\/jats:italic>\u2009=\u20090.04 compared to negative) among negative, untypable, and low\u2010risk HPV infection, respectively. The risk of cervical intraepithelial neoplasia associated with untypable HPV infection was higher than that recorded among uninfected women, but lower than the risk associated with low\u2010 or high\u2010risk HPV genotypes. <jats:bold><jats:italic>J. Med. Virol. 86:1145\u20131152, 2014<\/jats:italic>.<\/jats:bold> \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23938","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T12:05:49Z","timestamp":1396353949000},"page":"1145-1152","source":"Crossref","is-referenced-by-count":5,"title":["Untypable human papillomavirus infection and risk of cervical intraepithelial neoplasia among women with abnormal cervical cytology"],"prefix":"10.1002","volume":"86","author":[{"given":"Arsenio","family":"Spinillo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Pavia IRCCS Fondazione Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Gardella","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Pavia IRCCS Fondazione Policlinico San Matteo Pavia 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