{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:16:24Z","timestamp":1740104184036,"version":"3.37.3"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T00:00:00Z","timestamp":1398816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>Hepatitis C Virus (HCV) infection occurs frequently in patients with preexisting mental illness. Treatment for chronic hepatitis C using interferon formulations often increases risk for neuro\u2010psychiatric symptoms. Pegylated\u2010Interferon\u2010\u03b1 (PegIFN\u2010\u03b1) remains crucial for attaining sustained virologic response (SVR); however, PegIFN\u2010\u03b1 based treatment is associated with psychiatric adverse effects, which require dose reduction and\/or interruption. This study's main objective was to identify genes induced by PegIFN\u2010\u03b1 and expressed in the central nervous system and immune system, which could mediate the development of psychiatric toxicity in association with antiviral outcome. Using peripheral blood mononuclear cells from Human Immunodeficiency Virus (HIV)\/HCV co\u2010infected donors (N\u2009=\u200928), DNA microarray analysis was performed and 21 differentially regulated genes were identified in patients with psychiatric toxicity versus those without. Using these 21 expression profiles a two\u2010way\u2010ANOVA was performed to select genes based on antiviral outcome and occurrence of neuro\u2010psychiatric adverse events. Microarray analysis demonstrated that Interferon\u2010stimulated\u2010exonuclease\u2010gene 20\u2009kDa (ISG20) and Interferon\u2010alpha\u2010inducible\u2010protein 27 (IFI27) were the most regulated genes (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) between three groups that were built by combining antiviral outcome and neuro\u2010psychiatric toxicity. Validation by bDNA assay confirmed that ISG20 expression levels were significantly associated with these outcomes (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.035). Baseline levels and induction of ISG20 correlated independently with no occurrence of psychiatric adverse events and non\u2010response to therapy (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Among the 21 genes that were associated with psychiatric adverse events and 20 Interferon\u2010inducible genes (IFIGs) used as controls, only ISG20 expression was able to link PegIFN\u2010\u03b1 related neuro\u2010psychiatric toxicity to distinct HCV\u2010responses in patients co\u2010infected with HIV and HCV in vivo. <jats:bold><jats:italic>J. Med. Virol. 86:1323\u20131331, 2014<\/jats:italic>.<\/jats:bold> \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.23956","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T06:27:03Z","timestamp":1398839223000},"page":"1323-1331","source":"Crossref","is-referenced-by-count":2,"title":["Interferon stimulated exonuclease gene 20\u2009kDa links psychiatric events to distinct hepatitis C virus responses in human immunodeficiency virus positive patients"],"prefix":"10.1002","volume":"86","author":[{"given":"Antonios","family":"Katsounas","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Essen Hufelandstrasse 55 Essen 45147 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J.","family":"Rasimas","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health National 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