{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:09:06Z","timestamp":1790939346072,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":407,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Calouste Gulbenkian Foundation - Funda\u00ef\u00bf\u00bd\u00ef\u00bf\u00bdo Gulbenkian da Ci\u00ef\u00bf\u00bdncia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Virol."],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1002\/jmv.23986","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T04:27:07Z","timestamp":1405916827000},"page":"45-56","source":"Crossref","is-referenced-by-count":26,"title":["Influenza A(H1N1)pdm09 resistance and cross-decreased susceptibility to oseltamivir and zanamivir antiviral drugs"],"prefix":"10.1002","volume":"87","author":[{"given":"Vanessa","family":"Correia","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases; National Health Institute Doutor Ricardo Jorge; Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases; National Health Institute Doutor Ricardo Jorge; Lisbon Portugal"},{"name":"Centre for Molecular Pathogenesis-Retrovirus and Associated Infections Unit; Institute of Molecular Medicine and Drug Research Institute (iMed.ULisboa); Faculty of Pharmacy; University of Lisbon; Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"G\u00edria","sequence":"additional","affiliation":[{"name":"Centre for Molecular Pathogenesis-Retrovirus and Associated Infections Unit; Institute of Molecular Medicine and Drug Research Institute (iMed.ULisboa); Faculty of Pharmacy; University of Lisbon; Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Almeida-Santos","sequence":"additional","affiliation":[{"name":"Clinical Pathology Service, Laboratory of Microbiology, Virology and Molecular Biology; Hospital of Curry Cabral; Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Rebelo-de-Andrade","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases; National Health Institute Doutor Ricardo Jorge; Lisbon Portugal"},{"name":"Centre for Molecular Pathogenesis-Retrovirus and Associated Infections Unit; Institute of Molecular Medicine and Drug Research Institute (iMed.ULisboa); Faculty of Pharmacy; University of Lisbon; Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,21]]},"reference":[{"key":"10.1002\/jmv.23986-BIB0001|jmv23986-cit-0001","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/ncomms1390","article-title":"Mechanism of 150-cavity formation in influenza neuraminidase","volume":"2","author":"Amaro","year":"2011","journal-title":"Nat Commun"},{"key":"10.1002\/jmv.23986-BIB0002|jmv23986-cit-0002","unstructured":"AMC 2001 Robust statistics: A method of coping with outliers. AMC Technical Brief, No. 6 http:\/\/www.rsc.org\/images\/brief6_tcm18-25948.pdf"},{"key":"10.1002\/jmv.23986-BIB0003|jmv23986-cit-0003","first-page":"969","article-title":"Oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infection in two summer campers receiving prophylaxis-North Carolina, 2009","volume":"58","author":"CDC","year":"2009","journal-title":"Morb Mortal Wkly Rep"},{"key":"10.1002\/jmv.23986-BIB0004|jmv23986-cit-0004","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.antiviral.2010.01.002","article-title":"Antiviral drug profile of seasonal influenza viruses circulating in Portugal from 2004\/2005 to 2008\/2009 winter seasons","volume":"86","author":"Correia","year":"2010","journal-title":"Antiviral Res"},{"key":"10.1002\/jmv.23986-BIB0005|jmv23986-cit-0005","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nmeth.2109","article-title":"jModelTest 2: More models, new heuristics and parallel computing","volume":"9","author":"Darriba","year":"2012","journal-title":"Nat Methods"},{"key":"10.1002\/jmv.23986-BIB0006|jmv23986-cit-0006","volume-title":"Relat\u00f3rio da pandemia da gripe em Portugal","author":"DGS","year":"2010"},{"key":"10.1002\/jmv.23986-BIB0007|jmv23986-cit-0007","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1001\/jama.2009.1536","article-title":"Critically ill patients with 2009 influenza A(H1N1) in Mexico","volume":"302","author":"Dominguez-Cherit","year":"2009","journal-title":"JAMA"},{"key":"10.1002\/jmv.23986-BIB0008|jmv23986-cit-0008","unstructured":"ECDC 2009 First isolation of a secondary oseltamivir-resistant A(H1N1)v strain in Denmark-July 1, 2009 http:\/\/ecdc.europa.eu\/en\/healthtopics\/documents\/0906_influenza_ah1n1_ecdc_threat_assessment_first_isolation_of_a_secondary_oseltamivir_resistant_strain_in_denmark.pdf"},{"key":"10.1002\/jmv.23986-BIB0009|jmv23986-cit-0009","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jcv.2007.10.020","article-title":"Mutations of neuraminidase implicated in neuraminidase inhibitors resistance","volume":"41","author":"Ferraris","year":"2008","journal-title":"J Clin Virol"},{"key":"10.1002\/jmv.23986-BIB0010|jmv23986-cit-0010","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jcv.2011.11.002","article-title":"Genomic signatures and antiviral drug susceptibility profile of A(H1N1)pdm09","volume":"53","author":"Giria","year":"2012","journal-title":"J Clin Virol"},{"key":"10.1002\/jmv.23986-BIB0011|jmv23986-cit-0011","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/10635150390235520","article-title":"A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood","volume":"52","author":"Guindon","year":"2003","journal-title":"Syst Biol"},{"key":"10.1002\/jmv.23986-BIB0012|jmv23986-cit-0012","unstructured":"HPA 2006 Standard operating procedure for influenza MUNANA neuraminidase activity and inhibition assay (NO.V-66815) http:\/\/www.isirv.org\/site\/images\/stories\/avg_documents\/Methodology\/munana_ic50_sop_for_external.pdf"},{"key":"10.1002\/jmv.23986-BIB0013|jmv23986-cit-0013","unstructured":"HPA 2010 Standard operating procedure for pandemic 2009 H1N1 influenza A H275Y PCR and pyrosequencing (NO.V-6777) http:\/\/www.isirv.org\/site\/images\/stories\/avg_documents\/Methodology\/wm_v6777_pandemic%202009%20h1n1%20influenza%20a%20h275y%20pcr%20and%20pyrosequencing.pdf"},{"key":"10.1002\/jmv.23986-BIB0014|jmv23986-cit-0014","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/infdis\/jis337","article-title":"Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza in Australia","volume":"206","author":"Hurt","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1002\/jmv.23986-BIB0015|jmv23986-cit-0015","doi-asserted-by":"crossref","first-page":"e8553","DOI":"10.1371\/journal.pone.0008553","article-title":"Predicting the antigenic structure of the pandemic (H1N1) 2009 influenza virus hemagglutinin","volume":"5","author":"Igarashi","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1002\/jmv.23986-BIB0016|jmv23986-cit-0016","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1056\/NEJMoa0906695","article-title":"Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009","volume":"361","author":"Jain","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1002\/jmv.23986-BIB0017|jmv23986-cit-0017","doi-asserted-by":"crossref","first-page":"pii=19784","DOI":"10.2807\/ese.16.05.19784-en","article-title":"Continued emergence and changing epidemiology of oseltamivir-resistant influenza A(H1N1)2009 virus, United Kingdom, winter 2010\/11","volume":"16","author":"Lackenby","year":"2011","journal-title":"Euro Surveill"},{"key":"10.1002\/jmv.23986-BIB0018|jmv23986-cit-0018","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/nsmb.1909","article-title":"The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site","volume":"17","author":"Li","year":"2010","journal-title":"Nat Struct Mol Biol"},{"key":"10.1002\/jmv.23986-BIB0019|jmv23986-cit-0019","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1745-6150-4-18","article-title":"Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites","volume":"4","author":"Maurer-Stroh","year":"2009","journal-title":"Biol Direct"},{"key":"10.1002\/jmv.23986-BIB0020|jmv23986-cit-0020","doi-asserted-by":"crossref","first-page":"pii=698","DOI":"10.2807\/esm.12.04.00698-en","article-title":"Influenza antiviral susceptibility monitoring activities in relation to national antiviral stockpiles in Europe during the winter 2006\/2007 season","volume":"12","author":"Meijer","year":"2007","journal-title":"Euro Surveill"},{"key":"10.1002\/jmv.23986-BIB0021|jmv23986-cit-0021","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3851\/IMP2067","article-title":"Neuraminidase inhibitor resistance in influenza viruses and laboratory testing methods","volume":"17","author":"Nguyen","year":"2012","journal-title":"Antivir Ther"},{"key":"10.1002\/jmv.23986-BIB0022|jmv23986-cit-0022","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3201\/eid1406.070839","article-title":"Major issues and challenges of influenza pandemic preparedness in developing countries","volume":"14","author":"Oshitani","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1002\/jmv.23986-BIB0023|jmv23986-cit-0023","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.micinf.2011.01.009","article-title":"Overview\/reflections on the 2009 H1N1 pandemic","volume":"13","author":"Pada","year":"2011","journal-title":"Microbes Infect"},{"key":"10.1002\/jmv.23986-BIB0024|jmv23986-cit-0024","first-page":"294","article-title":"Genetic and antiviral drug susceptibility profiles of pandemic A(H1N1)v influenza virus circulating in Portugal","volume":"5","author":"Santos","year":"2011","journal-title":"Influenza Other Respir Viruses"},{"key":"10.1002\/jmv.23986-BIB0025|jmv23986-cit-0025","doi-asserted-by":"crossref","first-page":"pii=20666","DOI":"10.2807\/1560-7917.ES2014.19.1.20666","article-title":"A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013","volume":"19","author":"Takashita","year":"2014","journal-title":"Euro Surveill"},{"key":"10.1002\/jmv.23986-BIB0026|jmv23986-cit-0026","doi-asserted-by":"crossref","first-page":"e1002914","DOI":"10.1371\/journal.ppat.1002914","article-title":"H1N1 2009 pandemic influenza virus: Resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis","volume":"8","author":"van der Vries","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1002\/jmv.23986-BIB0027|jmv23986-cit-0027","doi-asserted-by":"crossref","first-page":"8593","DOI":"10.1128\/JVI.00769-07","article-title":"N-linked glycosylation attenuates H3N2 influenza viruses","volume":"81","author":"Vigerust","year":"2007","journal-title":"J Virol"},{"key":"10.1002\/jmv.23986-BIB0028|jmv23986-cit-0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4236\/jbise.2010.31001","article-title":"The interaction between the 2009 H1N1 influenza A hemagglutinin and neuraminidase: Mutations, co-mutations, and the NA stalk motifs","volume":"3","author":"Wei","year":"2010","journal-title":"J Biomed Sci Eng"},{"key":"10.1002\/jmv.23986-BIB0029|jmv23986-cit-0029","unstructured":"WHO 2005 WHO checklist for influenza pandemic preparedness planning http:\/\/www.who.int\/influenza\/resources\/documents\/FluCheck6web.pdf"},{"key":"10.1002\/jmv.23986-BIB0030|jmv23986-cit-0030","unstructured":"WHO 2009a Pandemic influenza preparedness and response: A WHO guidance document http:\/\/whqlibdoc.who.int\/publications\/2009\/9789241547680_eng.pdf"},{"key":"10.1002\/jmv.23986-BIB0031|jmv23986-cit-0031","unstructured":"WHO 2009b Sequencing primers and protocol http:\/\/www.who.int\/csr\/resources\/publications\/swineflu\/GenomePrimers_20090512.pdf"},{"key":"10.1002\/jmv.23986-BIB0032|jmv23986-cit-0032","first-page":"37","article-title":"Update on oseltamivir-resistant pandemic A (H1N1) 2009 influenza virus: January 2010","volume":"85","author":"WHO","year":"2010","journal-title":"Wkly Epidemiol Rec"},{"key":"10.1002\/jmv.23986-BIB0033|jmv23986-cit-0033","first-page":"497","article-title":"Global monitoring of antiviral resistance in currently circulating human influenza viruses, November 2011","volume":"86","author":"WHO","year":"2011a","journal-title":"Wkly Epidemiol Rec"},{"key":"10.1002\/jmv.23986-BIB0034|jmv23986-cit-0034","volume-title":"Report prepared for the WHO annual consultation on the composition of influenza vaccine for the Southern Hemisphere-September 26-30, 2011","author":"WHO","year":"2011b"},{"key":"10.1002\/jmv.23986-BIB0035|jmv23986-cit-0035","first-page":"369","article-title":"Meetings of the WHO working group on surveillance of influenza antiviral susceptibility-Geneva, November 2011 and June 2012","volume":"87","author":"WHO","year":"2012","journal-title":"Wkly Epidemiol Rec"},{"key":"10.1002\/jmv.23986-BIB0036|jmv23986-cit-0036","doi-asserted-by":"crossref","first-page":"RRN1152","DOI":"10.1371\/currents.RRN1152","article-title":"Structure and receptor binding properties of a pandemic H1N1 virus hemagglutinin","volume":"2","author":"Yang","year":"2010","journal-title":"PLoS Curr"},{"key":"10.1002\/jmv.23986-BIB0037|jmv23986-cit-0037","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0166-3542(01)00124-3","article-title":"Position statement: Global neuraminidase inhibitor susceptibility network","volume":"49","author":"Zambon","year":"2001","journal-title":"Antiv Res"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.23986","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jmv.23986\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T19:05:34Z","timestamp":1649703934000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.23986"}},"subtitle":["Resistance and Decreased Susceptibility to NAIs"],"short-title":[],"issued":{"date-parts":[[2014,7,21]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jmv.23986","relation":{},"ISSN":["0146-6615"],"issn-type":[{"value":"0146-6615","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7,21]]}}}