{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:15:11Z","timestamp":1761394511687},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T00:00:00Z","timestamp":1406764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Kawasaki research project grant","award":["B57"],"award-info":[{"award-number":["B57"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:label \/><jats:p>This study measured Varicella\u2010zoster virus (VZV) specific cell\u2010mediated immunity (CMI) and antibodies to clarify immune response after vaccination in 68 college students with negative or intermediate IgG antibody status. The enrolled numbers of negative, intermediate, and positive VZV\u2010IgG antibody were 27, 41, and 28 students, respectively. The positive rates of CMI were 3.7% (1\/27), 41.5% (17\/41), and 96.4% (27\/28) before vaccination, respectively. After vaccination, the IgG antibody titers became significantly higher in the intermediate IgG group compared to those in the negative IgG group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), but CMI did not differ significantly between the two groups. Ninety\u2010three percent (38\/41) of the intermediate IgG antibody group and 41% (11\/27) of the negative IgG antibody group became positive for the IgG antibody after vaccination (<jats:italic>P<\/jats:italic>\u2009<jats:italic>&lt;<\/jats:italic>\u20090.0001). When subjects were divided into negative, intermediate, and positive CMI by interferon\u2010gamma values before vaccination, the IgG antibody and interferon\u2010gamma values increased significantly in the positive CMI group compared to the negative CMI group after vaccination (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01 and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, respectively). All (17\/17) of positive CMI group and 61% (27\/44) of negative CMI group became positive for the IgG antibody after vaccination (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Ninety\u2010four percent (16\/17) of positive CMI group and 59% (28\/44) of negative CMI group became positive for CMI after vaccination (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Ninety\u2010six percent (22\/23) of the subjects with a history of vaccination became IgG seropositive after a second dose of vaccination, but 22% (5\/23) of them remained negative for CMI. CMI is valuable information to identify potential non\u2010responders to vaccination and to predict risk of clinical VZV infection. <jats:bold><jats:italic>J. Med. Virol. 87:350\u2013356, 2015<\/jats:italic>.<\/jats:bold> \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24031","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T08:58:53Z","timestamp":1406797133000},"page":"350-356","source":"Crossref","is-referenced-by-count":11,"title":["Varicella\u2010zoster virus\u2010specific, cell\u2010mediated immunity with interferon\u2010gamma release assay after vaccination of college students with no or intermediate IgG antibody response"],"prefix":"10.1002","volume":"87","author":[{"given":"Kihei","family":"Terada","sequence":"first","affiliation":[{"name":"Pediatrics Kawasaki Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Itoh","sequence":"additional","affiliation":[{"name":"Pediatrics Kawasaki Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihide","family":"Fujii","sequence":"additional","affiliation":[{"name":"Infection Control Team Kawasaki Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Infection Control Team Kawasaki Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Ogita","sequence":"additional","affiliation":[{"name":"Pediatrics Kawasaki Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunobu","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Pediatrics Kawasaki Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/338959"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109739"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.01.015"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa064040"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.11.022"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/149.2.137"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2005.06.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-005-0033-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000109287.97518.67"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/379048"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010801938215"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-32636-7_3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/529043"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2009.09.010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.11.040193.001555"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/592219"},{"key":"e_1_2_6_18_1","first-page":"489","article-title":"Abdominal presentation of varicella\u2010zoster infection in recipients of allogeneic bone marrow transplantation","volume":"7","author":"Schiller GJ","year":"1991","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1128\/CDLI.8.5.871-879.2001","article-title":"Development and validation of a gamma interferon ELISPOT assay for quantification of cellular immune responses to varicella\u2010zoster virus","volume":"8","author":"Smith JG","year":"2001","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.7.851"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/426866"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.24031","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.24031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:49:04Z","timestamp":1696333744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.24031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,31]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1002\/jmv.24031"],"URL":"https:\/\/doi.org\/10.1002\/jmv.24031","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,31]]}}}