{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:31:41Z","timestamp":1791160301618,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Research Foundation International","doi-asserted-by":"publisher","award":["5-2013-261"],"award-info":[{"award-number":["5-2013-261"]}],"id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Enterovirus infections are generally acute and rapidly cleared by the host immune response. Enteroviruses can at times persist in immunologically intact individuals after the rise of the type\u2010specific neutralizing immune response. The mechanism of enterovirus persistence was shown in group B coxsackieviruses (CVB) to be due to naturally\u2010occurring deletions at the 5\u2032 terminus of the genome which variably impact the stem\u2010loop secondary structure called domain I. These deletions result in much slower viral replication and a loss of measurable cytopathic effect when such 5\u2032 terminally deleted (TD) viruses are assayed in cell culture. The existence and persistence of CVB\u2010TD long after the acute phase of infection has been documented in hearts of experimentally inoculated mice and naturally infected humans but to date, the existence of TD enteroviral populations have not been documented in any other organ. Enteroviral infections have been shown to impact type 1 diabetes (T1D) onset in humans as well as in the non\u2010obese diabetic mouse model of T1D. The first step to studying the potential impact of CVB\u2010TD on T1D etiology is to determine whether CVB\u2010TD populations can arise in the pancreas. After inoculation of NOD diabetic mice with CVB, viral RNA persists in the absence of cytopathic virus in pancreas weeks past the acute infectious period. Analysis of viral genomic 5\u2032 termini by RT\u2010PCR showed CVB\u2010TD populations displace the parental population during persistent replication in murine pancreata.\n                      <jats:bold>\n                        <jats:italic>J. Med. Virol. 87:240\u2013247, 2015<\/jats:italic>\n                        .\n                      <\/jats:bold>\n                      \u00a9 2014 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.24039","type":"journal-article","created":{"date-parts":[[2014,8,16]],"date-time":"2014-08-16T06:25:52Z","timestamp":1408170352000},"page":"240-247","source":"Crossref","is-referenced-by-count":70,"title":["Coxsackievirus can persist in murine pancreas by deletion of 5\u2032 terminal genomic sequences"],"prefix":"10.1002","volume":"87","author":[{"given":"Steven","family":"Tracy","sequence":"first","affiliation":[{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Smithee","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz","family":"Alhazmi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Chapman","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10340"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb06032.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199706)52:2<121::AID-JMV1>3.0.CO;2-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)80006-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/9442"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05415-0"},{"key":"e_1_2_6_8_1","first-page":"13","article-title":"Coxsackie B viruses and human heart disease","volume":"223","author":"Baboonian C","year":"1997","journal-title":"Curr Topcs Microbiol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.381"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.6.1439"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-75546-3_6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-75546-3_13"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4161\/isl.21570"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.02.030"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91270-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a007682"},{"key":"e_1_2_6_17_1","first-page":"100","article-title":"Myocarditis in newborns, caused by coxsackie virus; clinical and pathological data. Annales paediatrici","volume":"187","author":"De Jager H","year":"1956","journal-title":"Int Rev Pediat"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.06.049"},{"key":"e_1_2_6_19_1","first-page":"1515","article-title":"Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice","volume":"119","author":"Filippi CM","year":"2009","journal-title":"J Clin Inevst"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.15.2293"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2741\/928"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2005.07.006"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02361-05"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1542\/peds.22.5.857","article-title":"Severe generalized disease (encephalohepatomyocarditis) occurring in the newborn period and due to infection with Coxsackie virus, group B; evidence of intrauterine infection with this agent","volume":"22","author":"Kibrick S","year":"1958","journal-title":"Pediatr"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01774-07"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.11.7024-7041.2005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.314"},{"key":"e_1_2_6_28_1","unstructured":"KnowlesN.2014.Nick Knowles' Virus Pages.http:\/\/www.iah\u2010virus.org\/"},{"key":"e_1_2_6_29_1","first-page":"855","volume-title":"Virus taxonomy: Classification and nomenclature of viruses: Ninth report of the international committee on taxonomy of viruses","author":"Knowles N","year":"2012"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-75546-3_15"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.548156"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01612-12"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.12.009"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555818326.ch14"},{"key":"e_1_2_6_35_1","first-page":"490","volume-title":"Fields virology, vol. 1, 6 ed","author":"Pallansch M","year":"2013"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.010"},{"key":"e_1_2_6_37_1","first-page":"1124","article-title":"Poly (rC) binding protein 2 forms a ternary complex with the 5'\u2010terminal sequences of poliovirus RNA and the viral 3CD proteinase","volume":"3","author":"Parsley TB","year":"1997","journal-title":"RNA"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.7.889"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12081"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1028"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2745-4"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-75546-3_10"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12056"},{"key":"e_1_2_6_44_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-3-540-75546-3_5","article-title":"Coxsackievirus B RNA replication: lessons from poliovirus","volume":"323","author":"Sean P","year":"2008","journal-title":"Curr Top Microbiol"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.07.039"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2008.07.027"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.12.6654-6660.1991"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.8.3841-3850.2001"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1255"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.639"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200009)62:1<70::AID-JMV11>3.0.CO;2-R"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.23.12097-12111.2002"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.22063"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.6.2582"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01649038"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2192-7"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.69.6.3658-3667.1995"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d35"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.6.1964"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.24039","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.24039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:49:28Z","timestamp":1696319368000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.24039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,11]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1002\/jmv.24039"],"URL":"https:\/\/doi.org\/10.1002\/jmv.24039","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718527698.793534858","asserted-by":"object"}]},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,11]]}}}