{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T01:38:27Z","timestamp":1726364307863},"reference-count":67,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>A 71\u2010year\u2010old (C1I) and 69\u2010year\u2010old (C2I) Japanese female contracted fulminant hepatitis B after 50 and 49 years of marriage, respectively. Both index cases exhibited high levels of anti\u2010HBc IgM antibodies (24.2 and 31.5 S\/CO, respectively), suggestive of acute hepatitis B virus (HBV) infection, although they had no discernible risk factors for HBV infection, except for chronically HBV\u2010infected spouses with detectable HBV DNA (3.3 log copies\/ml [C1S: 72\u2010year\u2010old] and 7.2 log copies\/ml [C2S: 71\u2010year\u2010old]). The HBV genotype\/subgenotype was identical in each couple (B\/B1 or C\/C2). The HBV isolates from the index cases and spouses shared a nucleotide sequence identity of 99.5% and 99.7%, respectively, over the entire genome, and these four isolates had the highest nucleotide sequence identity of only 97% to HBV isolates deposited in DNA databases. Phylogenetic trees confirmed a close relationship of the HBV isolates between C1I and C1S and between C2I and C2S, supported by a high bootstrap value of 100% within each couple, indicating the transfer of HBV infection between spouses. These four isolates shared a precore mutation of G1896A known to be associated with fulminant hepatitis B. Although the history of sexual contact within a reasonable incubation period was obscure for one stable, monogamous couple (C1I and C1S), the other couple had a monogamous sexual relationship within six months prior to disease onset. This study indicates that two elderly Japanese patients with fulminant hepatitis B acquired HBV infection via interspousal (most likely sexual) transmission during long\u2010lasting marriages. <jats:bold><jats:italic>J. Med. Virol. 86:1851\u20131860, 2014<\/jats:italic>.<\/jats:bold> \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24040","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T21:35:21Z","timestamp":1407965721000},"page":"1851-1860","source":"Crossref","is-referenced-by-count":5,"title":["Molecular analysis of the interspousal transmission of hepatitis B virus in two Japanese patients who acquired fulminant hepatitis B after 50 and 49 years of marriage"],"prefix":"10.1002","volume":"86","author":[{"given":"Daisuke","family":"Okamoto","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Iwaki Kyoritsu General Hospital Fukushima\u2010Ken Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Iwaki Kyoritsu General Hospital Fukushima\u2010Ken Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Iwaki Kyoritsu General Hospital Fukushima\u2010Ken Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Ikeya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Iwaki Kyoritsu General Hospital Fukushima\u2010Ken Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Division of Virology Department of Infection and Immunity Jichi Medical University School of Medicine Tochigi\u2010Ken Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Virology Department of Infection and Immunity Jichi Medical University School of Medicine Tochigi\u2010Ken Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Sugai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Iwaki Kyoritsu General Hospital Fukushima\u2010Ken Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Virology Department of Infection and Immunity Jichi Medical University School of Medicine Tochigi\u2010Ken Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.54.373"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-83-8-2059"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113406"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/52.1.31"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90713-7"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90112-1"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq313"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602293340901"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.11.1630"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20363"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.06.011"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26635"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114834"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s535-002-8130-z"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90286-T"},{"key":"e_1_2_5_17_1","first-page":"A367","article-title":"A case of fulminant hepatitis B via interspousal transmission after delivery of four children who had been married for years to her HBV\u2010carrier spouse","volume":"107","author":"Kou K","year":"2010","journal-title":"J Jpn Soc Gastroenterol"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(03)00168-2"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2009.00519.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2003.00487.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22881"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242405"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)90132-6"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90599-G"},{"key":"e_1_2_5_25_1","first-page":"445","volume-title":"Virus Taxonomy. 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