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Participants with community acquired acute respiratory infection underwent nasal lavage for IL\u20108 and neutrophil testing, in addition to multiplex polymerase chain reaction (PCR) methods for the detection and identification of respiratory viruses. Information about symptoms was obtained throughout the duration of the illness episode using the well\u2010validated Wisconsin Upper Respiratory Symptom Survey (WURSS\u201021). Global symptom severity was calculated by the area under the curve (AUC) plotting duration versus WURSS total. Of the specimens tested, 56% were positively identified for one or more of nine different respiratory viruses. During acute respiratory infection illness, both IL\u20108 and neutrophils positively correlate with AUC (r<jats:sub>s<\/jats:sub>\u2009=\u20090.082, <jats:italic>P<\/jats:italic>\u2009=\u20090.022; r<jats:sub>s<\/jats:sub>\u2009=\u20090.080, <jats:italic>P<\/jats:italic>\u2009=\u20090.030). IL\u20108 and neutrophils correlate with nasal symptom severity: runny nose (r\u2009=\u20090.13, <jats:italic>P<\/jats:italic>\u2009=\u2009&lt;\u20090.00001; r\u2009=\u20090.18, <jats:italic>P<\/jats:italic>\u2009=\u2009&lt;\u20090.003), plugged nose (r\u2009=\u20090.045, <jats:italic>P<\/jats:italic>\u2009=\u20090.003; r\u2009=\u20090.14, <jats:italic>P<\/jats:italic>\u2009=\u20090.058), and sneezing (r\u2009=\u2009\u22120.02, <jats:italic>P<\/jats:italic>\u2009=\u2009&lt;\u20090.0001; r\u2009=\u2009\u22120.0055, <jats:italic>P<\/jats:italic>\u2009=\u20090.31). Neutrophils correlate with some quality of life measures such as sleeping well (r\u2009=\u20090.15, <jats:italic>P<\/jats:italic>\u2009=\u20090.026). Thus, the study demonstrates that IL\u20108 and neutrophils are correlated with severity of nasal symptoms during acute respiratory infection. Further research is necessary to determine if the concentration of these or other biomarkers can predict the overall duration and severity of acute respiratory infection illness. <jats:bold><jats:italic>J. Med. Virol. 87:330\u2013337, 2015<\/jats:italic>.<\/jats:bold> \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24042","type":"journal-article","created":{"date-parts":[[2014,8,17]],"date-time":"2014-08-17T15:23:12Z","timestamp":1408288992000},"page":"330-337","source":"Crossref","is-referenced-by-count":34,"title":["Association of interleukin\u20108 and neutrophils with nasal symptom severity during acute respiratory infection"],"prefix":"10.1002","volume":"87","author":[{"given":"Kelsey M.","family":"Henriquez","sequence":"first","affiliation":[{"name":"School of Pharmacy University of Wisconsin\u2010Madison Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary S.","family":"Hayney","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Wisconsin\u2010Madison Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoguo","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Wisconsin\u2010Madison School of Medicine and Public Health Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Wisconsin\u2010Madison School of Medicine and Public Health Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Family Medicine University of Wisconsin\u2010Madison School of Medicine and Public Health Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"15","article-title":"Night work and inflammatory 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