{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:07:27Z","timestamp":1790615247848,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Institute of Biotechnology","award":["CS11-11"],"award-info":[{"award-number":["CS11-11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>Rubella virus (RV) infection is an unresolved clinical complication that affects children in developing countries including Vietnam. RV infection during the first trimester of pregnancy causes severe birth defects known as congenital rubella syndrome. This study reports on the genomic characterization of RV strains circulating in northern Vietnam during 2011\u20132013. RV\u2010IgM positive amniotic fluid specimens were collected from 38 women from northern Vietnam who presented with clinical rubella at the National Hospital of Obstetrics and Gynecology in Hanoi, Vietnam. The RV genes were determined by nested PCR with primers amplifying the 739\u2010nucleotide coding region of the E1 gene. The sequences from the amplified DNA fragments were phylogenetically analyzed and compared to reference RV strains. Seventeen out of 38 samples are positive for RV detecting. All new RV isolates are clustered to genotype 2B. Eighteen amino acid mutations were found in the T and B cell epitopes. These results suggest that genotype 2B RV strains frequently circulate in northern Vietnam. These data describe the RV genotype in Vietnam with the aim of improving maternal and child health in this country. <jats:bold><jats:italic>J. Med. Virol. 87:338\u2013343, 2015<\/jats:italic>.<\/jats:bold> \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24049","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T13:04:51Z","timestamp":1407762291000},"page":"338-343","source":"Crossref","is-referenced-by-count":3,"title":["Characterization of rubella virus genotypes among pregnant women in northern Vietnam, 2011\u20132013"],"prefix":"10.1002","volume":"87","author":[{"given":"Son","family":"Van Le","sequence":"first","affiliation":[{"name":"Laboratory of Applied DNA Technology, Institute of Biotechnology Vietnam Academy of Science and Technology Hanoi Vietnam"},{"name":"National Key Laboratory of Gene Technology, Institute of Biotechnology Vietnam Academy of Science and Technology Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc Hoang","family":"Le","sequence":"additional","affiliation":[{"name":"Laboratory of Applied DNA Technology, Institute of Biotechnology Vietnam Academy of Science and Technology Hanoi Vietnam"},{"name":"National Key Laboratory of Gene Technology, Institute of Biotechnology Vietnam Academy of Science and Technology Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huong Thi","family":"Hoang","sequence":"additional","affiliation":[{"name":"National Hospital of Obstetrics and Gynecology Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha","family":"Hoang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Gene Technology, Institute of Biotechnology Vietnam Academy of Science and Technology Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Trung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Laboratory of Applied DNA Technology, Institute of Biotechnology Vietnam Academy of Science and Technology Hanoi Vietnam"},{"name":"National Key Laboratory of Gene Technology, Institute of Biotechnology Vietnam Academy of Science and Technology Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Hoang","family":"Chu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Gene Technology, Institute of Biotechnology Vietnam Academy of Science and Technology Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-32"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002245"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15897-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01390-12"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-77-10-2523"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(92)90572-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00919265"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.8.4314-4322.2004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01311038"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(08)60328-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.4.854"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/515370"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00299-001-0399-7"},{"key":"e_1_2_6_15_1","first-page":"1069","volume-title":"Fields virology","author":"Hobman T","year":"2007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82580-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/514080"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088782"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2006.09.006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.6.1258"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890400302"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.02.008"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316681110"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.5365\/wpsar.2013.4.2.011"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msr121"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01322168"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23199"},{"key":"e_1_2_6_28_1","first-page":"397","article-title":"Viral molecular characterization of the first congenital rubella syndrome case in Vietnam","volume":"57","author":"Tran DN","year":"2011","journal-title":"Clin Lab"},{"key":"e_1_2_6_29_1","first-page":"126","article-title":"Standardization of the nomenclature for genetic characteristics of wild\u2010type rubella viruses","volume":"80","author":"World Health Organization (WHO)","year":"2005","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_6_30_1","first-page":"474","article-title":"Global distribution of measles and rubella genotypes\u2010update","volume":"81","author":"World Health Organization (WHO)","year":"2006","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_6_31_1","first-page":"209","article-title":"Update of standard nomenclature for wild\u2010type rubella viruses","volume":"82","author":"World Health Organization (WHO)","year":"2007","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0912.030242"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.24049","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.24049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:50:16Z","timestamp":1696333816000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.24049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,11]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1002\/jmv.24049"],"URL":"https:\/\/doi.org\/10.1002\/jmv.24049","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,11]]}}}