{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:15:30Z","timestamp":1793369730331,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T00:00:00Z","timestamp":1408924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>To predict the impact of current vaccines on cervical cancer and for the improvement of screening programs, regional data on distribution of human papillomavirus (HPV) types in women with or without cervical cancer is crucial. The present meta\u2010analysis intend to comprehensively evaluate the HPV burden in women with invasive cervical cancer, high\u2010grade squamous intraepithelial lesion (cervical intraepithelial neoplasia 2 and 3), low\u2010grade squamous intraepithelial lesion (cervical intraepithelial neoplasia 1), atypical squamous cells of undetermined significance and normal cytology, as these data will help decision making in regards with screening programs and HPV vaccination in Iran. To determine the HPV prevalence and type distribution in Iranian women with or without cervical cancer, 20 published studies were included in this meta\u2010analysis. In total, 713, 124, 104, 60, and 2577 women invasive cervical cancer, high\u2010grade squamous intraepithelial lesion (cervical intraepithelial neoplasia 2 and 3), low\u2010grade squamous intraepithelial lesion (cervical intraepithelial neoplasia 1), atypical squamous cells of undetermined significance and normal were reviewed, respectively. Overall HPV prevalence in women with invasive cervical cancer, high\u2010grade squamous intraepithelial lesion (cervical intraepithelial neoplasia 2 and 3), low\u2010grade squamous intraepithelial lesion (cervical intraepithelial neoplasia 1), atypical squamous cells of undetermined significance and normal cytology were 77.4%, 71.8%, 65.3%, 61.7%, and 8.4%, respectively. The six most common types were HPV 16, 18, 6\/11, 31, and 33; among them HPV 16 was the most frequent type in all five different groups. According to this study, it was estimated that HPV vaccines could have a great impact on prevention of cervical cancer in Iran. In conclusion, this meta\u2010analysis highlights the necessity of introducing vaccination program in Iran. <jats:bold><jats:italic>J. Med. Virol. 87:287\u2013295, 2015<\/jats:italic>.<\/jats:bold> \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24053","type":"journal-article","created":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T09:52:55Z","timestamp":1408960375000},"page":"287-295","source":"Crossref","is-referenced-by-count":36,"title":["Meta\u2010analysis of type\u2010specific human papillomavirus prevalence in Iranian women with normal cytology, precancerous cervical lesions and invasive cervical cancer: Implications for screening and vaccination"],"prefix":"10.1002","volume":"87","author":[{"given":"Somayeh","family":"Jalilvand","sequence":"first","affiliation":[{"name":"Virology Department School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zabihollah","family":"Shoja","sequence":"additional","affiliation":[{"name":"Virology Department Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keramat","family":"Nourijelyani","sequence":"additional","affiliation":[{"name":"Biostatistics Department School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid Reza","family":"Tohidi","sequence":"additional","affiliation":[{"name":"Faculty of Health Gonabad University of Medical Sciences Gonabad Iran"},{"name":"Non\u2010Communicable Diseases Research Center Endocrinology and Metabolism Population Science Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasool","family":"Hamkar","sequence":"additional","affiliation":[{"name":"Virology Department School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-1863-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00959.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0131"},{"key":"e_1_2_5_6_1","first-page":"C1","article-title":"HPV and cervical cancer in the World 2007 report","volume":"25","author":"Castellsagu\u00e9 X","year":"2007","journal-title":"Vaccine"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji186"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9422-z"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025493"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.026"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600688"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70086-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.038414"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.OLQ.0000080177.82204.E0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70158-5"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23333"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.083"},{"key":"e_1_2_5_18_1","first-page":"361","article-title":"PCR detection and high risk typing of human papillomavirus DNA in cervical cancer in Iranian women","volume":"6","author":"Eslami G","year":"2008","journal-title":"Cancer Therapy"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000134917"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033756"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.07.055"},{"key":"e_1_2_5_22_1","first-page":"529","article-title":"Prevalence of human papillomavirus genotypes in women with normal and abnormal cervical cytology in Iran","volume":"7","author":"Ghaffari SR","year":"2006","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-7-26"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.26719\/2002.8.6.805"},{"key":"e_1_2_5_25_1","article-title":"The frequency of high risk sub\u2010types of Human Papillomavirus in the samples with varying degrees of cervical neoplasia","volume":"28","author":"Heidarpour M","year":"2011","journal-title":"Journal of Isfahan Medical School"},{"key":"e_1_2_5_26_1","unstructured":"International Agency for Research on Cancer.GLOBOCAN 2012: Estimated cancer incidence mortality and prevalence worldwide in 2012.2012. 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