{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:37:11Z","timestamp":1791196631432,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T00:00:00Z","timestamp":1422921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>A new picornavirus, named human Cosavirus (HCoSV) was isolated recently from stools of children with acute flaccid paralysis (AFP) and healthy children in Pakistan and Afghanistan. Since then, it was also isolated from patients from other countries. Five species are presently identified forming a new genus in the <jats:italic>Picornaviridae<\/jats:italic> family. This study reports the detection of HCoSV in stool specimens collected as part of the National Poliovirus surveillance Program in Tunisia, between 2011 and 2012, from patients with AFP and healthy individuals among their contacts. One hundred and ninety four stool samples were investigated by RT\u2010PCR in the 5' non\u2010coding region of the genome. A total of 64 specimens (33%) tested positive for HCoSV. HCoSV positive specimens were found in 36 cases with neurological syndromes and 28 of their healthy contacts. The highest rate of HCoSV infection (62.5%) occurred in children younger than 6 years of age. The sampling date of stool specimens suggested that HCoSV infection occurred regularly over time. Also, the sampling origin of stool specimen showed that HCoSV infection was detected in almost all the governorates of Tunisia from the North to the South of the country. This study is the first report of HCoSV prevalence in the North African region. It contributes to a better knowledge on the geographic distribution and the epidemiology of these viruses. <jats:bold><jats:italic>J. Med. Virol. 87:940\u2013943, 2015<\/jats:italic>.<\/jats:bold> \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24076","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T17:11:24Z","timestamp":1422983484000},"page":"940-943","source":"Crossref","is-referenced-by-count":17,"title":["Prevalence of human cosaviruses in Tunisia, North Africa"],"prefix":"10.1002","volume":"87","author":[{"given":"Dorra","family":"Rezig","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Virology WHO Regional Reference Laboratory for Poliomyelitis and Measles, Institut Pasteur de Tunis Tunis\u2010Belv\u00e9d\u00e8re Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Essia Ben","family":"Farhat","sequence":"additional","affiliation":[{"name":"National Program of Immunization Basic Health Care Division\u2010 Ministry of Health Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henda","family":"Touzi","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Virology WHO Regional Reference Laboratory for Poliomyelitis and Measles, Institut Pasteur de Tunis Tunis\u2010Belv\u00e9d\u00e8re Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zina","family":"Meddeb","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Virology WHO Regional Reference Laboratory for Poliomyelitis and Measles, Institut Pasteur de Tunis Tunis\u2010Belv\u00e9d\u00e8re Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afif Ben","family":"Salah","sequence":"additional","affiliation":[{"name":"National Program of Immunization Basic Health Care Division\u2010 Ministry of Health Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henda","family":"Triki","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Virology WHO Regional Reference Laboratory for Poliomyelitis and Measles, Institut Pasteur de Tunis Tunis\u2010Belv\u00e9d\u00e8re Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01062-09"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.03.024"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-5-159"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807979105"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036685"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-011-0700-y"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.04.023"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.03.015"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01427-12"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1804.111415"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02301-08"},{"key":"e_1_2_5_13_1","unstructured":"World Health Organization (WHO).2004.Manual for virologic investigation of poliomyelitis. 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