{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:05:09Z","timestamp":1770149109370,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Indian Council of Medical Research, New Delhi, India"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>Japanese encephalitis (JE) is a major public health problem in Asia and worldwide and it is responsible mainly for viral acute encephalitis syndrome (AES). The sole etiologic agent of JE is Japanese encephalitis virus (JEV). Although JE\/AES cases have been regarded traditionally as a disease of children, a growing number of patients with JE\/AES cases are also seen in the adult age group every year in the state of West Bengal, India in spite of vaccination. Therefore, a systematic study was performed to differentiate and characterize the clinico\u2010pathological parameters and viral diversity among the patients of different age groups. Viral diversity was also evaluated from the JE\/AES cases, depending on their disease severity. A total of 441 JE\/AES cases were included in this study. By MAC\u2013ELISA, 111 samples were found JEV IgM positive and among the IgM negative cases, 26 samples were found RT\u2013PCR positive against JEV infection. Neck rigidity, abnormal behavior, convulsion, protein in CSF, WBC in CSF, and aspartate transaminase in blood differed significantly among the patients of pediatric\u2010adolescent and adult group in both IgM positive and RT\u2013PCR positive cases. Viral diversity was increased significantly in the pediatric\u2010adolescent group compared to adult patients. Interestingly, with the rise in disease severity the viral diversity was found to be increased among the patients, irrespective of their age distribution. Based on clinico\u2010pathological parameters and analysis of viral diversity, it can be concluded that viral diversity which occurs naturally is likely to affect disease severity, especially in the patients of pediatric\u2010adolescent group. <jats:bold><jats:italic>J. Med. Virol. 87:1258\u20131267, 2015<\/jats:italic>.<\/jats:bold> \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24165","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T18:45:42Z","timestamp":1430765142000},"page":"1258-1267","source":"Crossref","is-referenced-by-count":5,"title":["Japanese encephalitis associated acute encephalitis syndrome cases in West Bengal, India: A sero\u2010molecular evaluation in relation to clinico\u2010pathological spectrum"],"prefix":"10.1002","volume":"87","author":[{"given":"Arindam","family":"Sarkar","sequence":"first","affiliation":[{"name":"ICMR Virus, ID &amp; BG Hospital Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somenath","family":"Datta","sequence":"additional","affiliation":[{"name":"IPGME&amp;R Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bani K.","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Biotechnology St. Xavier's College Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhra K.","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Microbiology The University of Burdwan, Golapbag Burdwan West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyamalendu","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"ICMR Virus, ID &amp; BG Hospital Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.1986.1.1.21"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.06.001"},{"key":"e_1_2_7_4_1","first-page":"737","article-title":"Japanese encephalitis among three US travelers returning from Asia, 2003\u20132008","volume":"58","author":"Centers for Disease Control Prevention","year":"2009","journal-title":"MMWR Weekly"},{"key":"e_1_2_7_5_1","first-page":"121","article-title":"Inapparent infection by Japanese encephalitis (JE) virus in West Bengal Indian","volume":"24","author":"Chakraborty MS","year":"1981","journal-title":"J Public Health"},{"key":"e_1_2_7_6_1","unstructured":"Communicable Diseases\u2013Report of the Working Group on Disease Burden for the 12th Five Year Plan WG3 (1). 2011.http:\/\/planningcommission.nic.in\/aboutus\/committee\/wrkgrp12\/health\/WG_3_1communicable.pdf. 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