{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T23:19:20Z","timestamp":1774739960620,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":117,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81371815"],"award-info":[{"award-number":["81371815"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Basic Research Project of Shenzhen in 2012","award":["JCYJ20120615085419420"],"award-info":[{"award-number":["JCYJ20120615085419420"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Virol."],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1002\/jmv.24200","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T18:33:21Z","timestamp":1431023601000},"page":"1471-1479","source":"Crossref","is-referenced-by-count":59,"title":["Characterization of severe hand, foot, and mouth disease in Shenzhen, China, 2009-2013"],"prefix":"10.1002","volume":"87","author":[{"given":"Yun","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Epidemiology; School of Public Health and Tropical Medicine, Southern Medical University; Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanping","family":"Zhou","sequence":"additional","affiliation":[{"name":"First School of Clinical Medicine; Southern Medical University; Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Lu","sequence":"additional","affiliation":[{"name":"Scientific Research Department of Nanfang Hospital Affiliated to Southern Medical University; Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[{"name":"Major Infectious Disease Control Key Laboratory; Shenzhen Center for Disease Control and Prevention; Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianjin","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Health Statistics and Epidemiology; College of Public Health, Sun Yat-sen University; Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingchun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology; School of Public Health and Tropical Medicine, Southern Medical University; Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[{"name":"Major Infectious Disease Control Key Laboratory; Shenzhen Center for Disease Control and Prevention; Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouyi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology; School of Public Health and Tropical Medicine, Southern Medical University; Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangjie","family":"Yao","sequence":"additional","affiliation":[{"name":"Major Infectious Disease Control Key Laboratory; Shenzhen Center for Disease Control and Prevention; Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Major Infectious Disease Control Key Laboratory; Shenzhen Center for Disease Control and Prevention; Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Major Infectious Disease Control Key Laboratory; Shenzhen Center for Disease Control and Prevention; Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology; School of Public Health and Tropical Medicine, Southern Medical University; Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Tongji Medical College; Huazhong University of Science and Technology; Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology; School of Public Health and Tropical Medicine, Southern Medical University; Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqing","family":"He","sequence":"additional","affiliation":[{"name":"First School of Clinical Medicine; Southern Medical University; Guangzhou China"},{"name":"Major Infectious Disease Control Key Laboratory; Shenzhen Center for Disease Control and Prevention; Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,7]]},"reference":[{"key":"10.1002\/jmv.24200-BIB0001|jmv24200-cit-0001","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.3201\/eid1712.110395","article-title":"Enterovirus Co-infections and Onychomadesis after Hand, Foot, and Mouth Disease, Spain, 2008","volume":"17","author":"Bracho","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"10.1002\/jmv.24200-BIB0002|jmv24200-cit-0002","doi-asserted-by":"crossref","first-page":"e52432","DOI":"10.1371\/journal.pone.0052432","article-title":"Comparative genomic analysis of coxsackievirus A6 strains of different clinical disease entities","volume":"7","author":"Brown","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1002\/jmv.24200-BIB0003|jmv24200-cit-0003","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3201\/eid0904.020395","article-title":"Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: Comparative analysis of the VP1 and VP4 genes","volume":"9","author":"Cardosa","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"10.1002\/jmv.24200-BIB0004|jmv24200-cit-0004","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1086\/314032","article-title":"Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: Clinical and pathological characteristics of the disease. For the Outbreak Study Group","volume":"31","author":"Chan","year":"2000","journal-title":"Clin Infect Dis"},{"key":"10.1002\/jmv.24200-BIB0005|jmv24200-cit-0005","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3201\/eid1301.020112","article-title":"Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore","volume":"9","author":"Chan","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"10.1002\/jmv.24200-BIB0006|jmv24200-cit-0006","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0929-6646(09)60236-9","article-title":"Hand, foot and mouth disease complicated with central nervous system involvement in Taiwan in 1980-1981","volume":"106","author":"Chang","year":"2007","journal-title":"J Formos Med Assoc"},{"key":"10.1002\/jmv.24200-BIB0007|jmv24200-cit-0007","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/jmv.23287","article-title":"Genetic characterization of enterovirus 71 isolated from patients with severe disease by comparative analysis of complete genomes","volume":"84","author":"Chang","year":"2012","journal-title":"J Med Virol"},{"key":"10.1002\/jmv.24200-BIB0008|jmv24200-cit-0008","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.1542\/peds.2006-3331","article-title":"Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005","volume":"120","author":"Chen","year":"2007a","journal-title":"Pediatrics"},{"key":"10.1002\/jmv.24200-BIB0009|jmv24200-cit-0009","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4269\/ajtmh.2007.77.188","article-title":"An eight-year study of epidemiologic features of enterovirus 71 infection in Taiwan","volume":"77","author":"Chen","year":"2007b","journal-title":"Am J Trop Med Hyg"},{"key":"10.1002\/jmv.24200-BIB0010|jmv24200-cit-0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1525-1470.2010.01161.x","article-title":"Onychomadesis outbreak in Valencia, Spain associated with hand, foot, and mouth disease caused by enteroviruses","volume":"28","author":"Davia","year":"2011","journal-title":"Pediatr Dermatol"},{"key":"10.1002\/jmv.24200-BIB0011|jmv24200-cit-0011","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/1743-422X-11-157","article-title":"Circulation of Coxsackievirus A6 in hand-foot-mouth disease in Guangzhou, 2010-2012","volume":"11","author":"Di","year":"2014","journal-title":"Virol J"},{"key":"10.1002\/jmv.24200-BIB0012|jmv24200-cit-0012","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1348-0421.2002.tb02743.x","article-title":"Outbreak of central nervous system disease associated with hand, foot, and mouth disease in Japan during the summer of 2000: Detection and molecular epidemiology of enterovirus 71","volume":"46","author":"Fujimoto","year":"2002","journal-title":"Microbiol Immunol"},{"key":"10.1002\/jmv.24200-BIB0013|jmv24200-cit-0013","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3201\/eid1802.111147","article-title":"Hand, foot, and mouth disease caused by coxsackievirus A6, Japan, 2011","volume":"18","author":"Fujimoto","year":"2012","journal-title":"Emerg Infect Dis"},{"key":"10.1002\/jmv.24200-BIB0014|jmv24200-cit-0014","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jinf.2014.03.015","article-title":"Hand, foot, and mouth disease outbreak caused by coxsackievirus A6, China, 2013","volume":"69","author":"Han","year":"2014","journal-title":"J Infect"},{"key":"10.1002\/jmv.24200-BIB0015|jmv24200-cit-0015","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/jpc.12708","article-title":"Outbreak of variant hand-foot-and-mouth disease caused by coxsackievirus A6 in Auckland, New Zealand","volume":"50","author":"Hayman","year":"2014","journal-title":"J Paediatr Child Health"},{"key":"10.1002\/jmv.24200-BIB0016|jmv24200-cit-0016","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1128\/JCM.01231-13","article-title":"Emergence, circulation, and spatiotemporal phylogenetic analysis of coxsackievirus a6- and coxsackievirus a10-associated hand, foot, and mouth disease infections from 2008 to 2012 in Shenzhen, China","volume":"51","author":"He","year":"2013","journal-title":"J Clin Microbiol"},{"key":"10.1002\/jmv.24200-BIB0017|jmv24200-cit-0017","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1743-422X-10-209","article-title":"Atypical hand-foot-mouth disease in children: A hospital-based prospective cohort study","volume":"10","author":"Huang","year":"2013","journal-title":"Virol J"},{"key":"10.1002\/jmv.24200-BIB0018|jmv24200-cit-0018","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1007\/s00705-003-0133-6","article-title":"Genetic analysis of the VP1 region of human enterovirus 71 strains isolated in Korea during 2000","volume":"148","author":"Jee","year":"2003","journal-title":"Arch Virol"},{"key":"10.1002\/jmv.24200-BIB0019|jmv24200-cit-0019","doi-asserted-by":"crossref","first-page":"e80515","DOI":"10.1371\/journal.pone.0080515","article-title":"Seroprevalence of human enterovirus 71 and coxsackievirus A16 in Guangdong, China, in pre- and post-2010 HFMD epidemic period","volume":"8","author":"Li","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1002\/jmv.24200-BIB0020|jmv24200-cit-0020","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1086\/345905","article-title":"Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous system","volume":"36","author":"Lin","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1002\/jmv.24200-BIB0021|jmv24200-cit-0021","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1386-6532(00)00068-8","article-title":"An outbreak of enterovirus 71 infection in Taiwan, 1998: Epidemiologic and clinical manifestations","volume":"17","author":"Liu","year":"2000","journal-title":"J Clin Virol"},{"key":"10.1002\/jmv.24200-BIB0022|jmv24200-cit-0022","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jmii.2011.01.031","article-title":"Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009","volume":"44","author":"Lo","year":"2011","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1002\/jmv.24200-BIB0023|jmv24200-cit-0023","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jaad.2013.07.024","article-title":"Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection","volume":"69","author":"Lott","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1002\/jmv.24200-BIB0024|jmv24200-cit-0024","doi-asserted-by":"crossref","first-page":"O442","DOI":"10.1111\/1469-0691.12468","article-title":"Hand, foot and mouth disease in Guangdong, China, in 2013: New trends in the continuing epidemic","volume":"20","author":"Lu","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"10.1002\/jmv.24200-BIB0025|jmv24200-cit-0025","doi-asserted-by":"crossref","first-page":"422","DOI":"10.7883\/yoken.63.422","article-title":"Changing epidemiology of hand, foot, and mouth disease in Hong Kong, 2001-2009","volume":"63","author":"Ma","year":"2010","journal-title":"Jpn J Infect Dis"},{"key":"10.1002\/jmv.24200-BIB0026|jmv24200-cit-0026","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1086\/318454","article-title":"Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia","volume":"32","author":"McMinn","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1002\/jmv.24200-BIB0027|jmv24200-cit-0027","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1128\/JCM.01020-07","article-title":"Prospective identification of enteroviruses involved in meningitis in 2006 through direct genotyping in cerebrospinal fluid","volume":"46","author":"Mirand","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1002\/jmv.24200-BIB0028|jmv24200-cit-0028","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1099\/vir.0.021741-0","article-title":"Phylogenetic evidence for a recent spread of two populations of human enterovirus 71 in European countries","volume":"91","author":"Mirand","year":"2010","journal-title":"J Gen Virol"},{"key":"10.1002\/jmv.24200-BIB0029|jmv24200-cit-0029","doi-asserted-by":"crossref","first-page":"E110","DOI":"10.1111\/j.1469-0691.2012.03789.x","article-title":"Outbreak of hand, foot and mouth disease\/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: A large citywide, prospective observational study","volume":"18","author":"Mirand","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"10.1002\/jmv.24200-BIB0030|jmv24200-cit-0030","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1017\/S0950268813001453","article-title":"Severe hand, foot and mouth disease in Shenzhen, South China: What matters most","volume":"142","author":"Mou","year":"2013","journal-title":"Epidemiol Infect"},{"key":"10.1002\/jmv.24200-BIB0031|jmv24200-cit-0031","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1017\/S0950268813001453","article-title":"Severe hand, foot and mouth disease in Shenzhen, South China: What matters most","volume":"142","author":"Mou","year":"2014","journal-title":"Epidemiol Infect"},{"key":"10.1002\/jmv.24200-BIB0032|jmv24200-cit-0032","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1128\/JCM.00542-06","article-title":"Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens","volume":"44","author":"Nix","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1002\/jmv.24200-BIB0033|jmv24200-cit-0033","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/jmv.21374","article-title":"Epidemiology of enterovirus types causing neurological disease in Austria 1999-2007: Detection of clusters of echovirus 30 and enterovirus 71 and analysis of prevalent genotypes","volume":"81","author":"Ortner","year":"2009","journal-title":"J Med Virol"},{"key":"10.1002\/jmv.24200-BIB0034|jmv24200-cit-0034","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.3201\/eid1509.090438","article-title":"Coxsackievirus A6 and Hand, Foot, and Mouth Disease, Finland","volume":"15","author":"\u00d6sterback","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"10.1002\/jmv.24200-BIB0035|jmv24200-cit-0035","doi-asserted-by":"crossref","first-page":"e32405","DOI":"10.1371\/journal.pone.0032405","article-title":"Characterization of full-length enterovirus 71 strains from severe and mild disease patients in northeastern China","volume":"7","author":"Pyrc","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1002\/jmv.24200-BIB0036|jmv24200-cit-0036","doi-asserted-by":"crossref","first-page":"20745","DOI":"10.2807\/1560-7917.ES2014.19.12.20745","article-title":"Atypical hand, foot, and mouth disease associated with coxsackievirus A6 infection, Edinburgh, United Kingdom, January to February 2014","volume":"19","author":"Sinclair","year":"2014","journal-title":"Euro Surveill"},{"key":"10.1002\/jmv.24200-BIB0037|jmv24200-cit-0037","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.3201\/eid1311.070632","article-title":"Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005","volume":"13","author":"Tu","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"10.1002\/jmv.24200-BIB0038|jmv24200-cit-0038","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/1471-2334-11-346","article-title":"An outbreak of coxsackievirus A6 hand, foot, and mouth disease associated with onychomadesis in Taiwan, 2010","volume":"11","author":"Wei","year":"2011","journal-title":"BMC Infect Dis"},{"key":"10.1002\/jmv.24200-BIB0039|jmv24200-cit-0039","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.micinf.2010.03.006","article-title":"Neural pathogenesis of enterovirus 71 infection","volume":"12","author":"Weng","year":"2010","journal-title":"Microbes Infect"},{"key":"10.1002\/jmv.24200-BIB0040|jmv24200-cit-0040","doi-asserted-by":"crossref","first-page":"e1076","DOI":"10.1016\/j.ijid.2010.07.006","article-title":"The largest outbreak of hand; foot and mouth disease in Singapore in 2008: The role of enterovirus 71 and coxsackievirus A strains","volume":"14","author":"Wu","year":"2010","journal-title":"Int J Infect Dis"},{"key":"10.1002\/jmv.24200-BIB0041|jmv24200-cit-0041","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1743-422X-9-8","article-title":"Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications","volume":"9","author":"Xu","year":"2012","journal-title":"Virol J"},{"key":"10.1002\/jmv.24200-BIB0042|jmv24200-cit-0042","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1128\/JCM.00563-09","article-title":"Enterovirus 71 outbreak in the People's Republic of China in 2008","volume":"47","author":"Yang","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1002\/jmv.24200-BIB0043|jmv24200-cit-0043","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jcv.2009.02.002","article-title":"An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China","volume":"44","author":"Zhang","year":"2009","journal-title":"J Clin Virol"},{"key":"10.1002\/jmv.24200-BIB0044|jmv24200-cit-0044","first-page":"214","article-title":"Characterization of hand, foot, and mouth disease in China between 2008 and 2009","volume":"24","author":"Zhang","year":"2011","journal-title":"Biomed Environ Sci"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.24200","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jmv.24200\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T13:14:38Z","timestamp":1651929278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.24200"}},"subtitle":["Characterization of Severe Hand, Foot, and Mouth Disease"],"short-title":[],"issued":{"date-parts":[[2015,5,7]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"URL":"https:\/\/doi.org\/10.1002\/jmv.24200","archive":["Portico"],"relation":{},"ISSN":["0146-6615"],"issn-type":[{"value":"0146-6615","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5,7]]}}}