{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:19:17Z","timestamp":1765700357154},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:label \/><jats:p>Although several vitamin D\u2010related gene polymorphisms were reported to affect the outcome of pegylated interferon\/ribavirin (PR) therapy in chronic hepatitis C patients, there are no reports on the impact of the vitamin D\u2010related gene polymorphisms in PR therapy combined with protease inhibitor (PI). Vitamin D\u2010related gene polymorphisms were determined in 177 genotype 1b\u2010infected chronic hepatitis C patients who received 12 weeks of PR therapy with telaprevir, a first\u2010generation PI, followed by 12 weeks of PR therapy. The sustained virologic response (SVR) rate was 83.1% (147 of 177 patients). The frequencies of vitamin D\u2010related gene polymorphisms were: 83 non\u2010TT and 94 TT genotypes for GC, 97 non\u2010AA and 80 AA genotypes for <jats:italic>DHCR7<\/jats:italic>, 151 non\u2010AA and 26 AA genotypes for <jats:italic>CYP2R1<\/jats:italic>, 162 non\u2010GG and 15 GG genotypes for <jats:italic>CYP27B1<\/jats:italic>, and 105 non\u2010GG and 72 GG genotypes for <jats:italic>VDR gene<\/jats:italic>. Multivariate analysis extracted <jats:italic>IL28B<\/jats:italic> TT genotype (<jats:italic>P<\/jats:italic>\u2009=\u20092.05\u00d710<jats:sup>\u22126<\/jats:sup>) and serum 25(OH) D<jats:sub>3<\/jats:sub> level (<jats:italic>P<\/jats:italic>\u2009=\u20090.024) as independent factors contributing to the achieving of SVR. The SVR rate in <jats:italic>IL28B<\/jats:italic> TT genotype patients with serum 25(OH) D<jats:sub>3<\/jats:sub> level of &lt;25\u2009ng\/ml was significantly low compared to other patients. None of the vitamin D\u2010related gene polymorphisms affected the treatment outcome and serum 25(OH) D<jats:sub>3<\/jats:sub> level. In conclusions, the <jats:italic>IL28B<\/jats:italic> polymorphism and serum 25(OH) D<jats:sub>3<\/jats:sub> level contributed significantly and independently to SVR in PR combined with PI for genotype 1b\u2010infected chronic hepatitis C patients. However, none of vitamin D\u2010related gene polymorphisms had an impact on the treatment outcome and serum 25(OH) D<jats:sub>3<\/jats:sub> level. <jats:bold><jats:italic>J. Med. Virol. 87:1904\u20131912, 2015<\/jats:italic>.<\/jats:bold> \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24244","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T16:40:18Z","timestamp":1431362418000},"page":"1904-1912","source":"Crossref","is-referenced-by-count":8,"title":["Vitamin D\u2010related gene polymorphisms do not influence the outcome and serum vitamin D level in pegylated interferon\/ribavirin therapy combined with protease inhibitor for patients with genotype 1b chronic hepatitis C"],"prefix":"10.1002","volume":"87","author":[{"given":"Taeang","family":"Arai","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Nippon Medical School Chiba Hokusoh Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Atsukawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Nippon Medical School Chiba Hokusoh Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Tsubota","sequence":"additional","affiliation":[{"name":"Core Research Facilities for Basic Science Research Center for Medical Sciences Jikei University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisa","family":"Kondo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Nippon Medical School Chiba Hokusoh Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noritomo","family":"Shimada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Chiba Tokushukai Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and 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