{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:31:51Z","timestamp":1777728711814,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation of China","doi-asserted-by":"crossref","award":["07JJ5055"],"award-info":[{"award-number":["07JJ5055"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:label\/><jats:p>To explore the epidemiological and clinical features of different human metapneumovirus (hMPV) genotypes in hospitalized children. Reverse transcription polymerase chain reaction (RT\u2010PCR) or PCR was employed to screen for both hMPV and other common respiratory viruses in 2613 nasopharyngeal aspirate specimens collected from children with lower respiratory tract infections from September 2007 to February 2011 (a period of 3.5 years). The demographics and clinical presentations of patients infected with different genotypes of hMPV were compared. A total of 135 samples were positive for hMPV (positive detection rate: 5.2%). Co\u2010infection with other viruses was observed in 45.9% (62\/135) of cases, and human bocavirus was the most common additional respiratory virus. The most common symptoms included cough, fever, and wheezing. The M gene was sequenced for 135 isolates; of these, genotype A was identified in 72.6% (98\/135) of patients, and genotype B was identified in 27.4% (37\/135) of patients. The predominant genotype of hMPV changed over the 3.5\u2010year study period from genotype A2b to A2b or B1 and then to predominantly B1. Most of clinical features were similar between patients infected with different hMPV genotypes. These results suggested that hMPV is an important viral pathogen in pediatric patients with acute lower respiratory tract infection in Changsha. The hMPV subtypes A2b and B1 were found to co\u2010circulate. The different hMPV genotypes exhibit similar clinical characteristics. <jats:bold><jats:italic>J. Med. Virol. 87:1839\u20131845, 2015<\/jats:italic>.<\/jats:bold> \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24249","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T22:58:55Z","timestamp":1430953135000},"page":"1839-1845","source":"Crossref","is-referenced-by-count":20,"title":["Clinical features of human metapneumovirus genotypes in children with acute lower respiratory tract infection in Changsha, China"],"prefix":"10.1002","volume":"87","author":[{"given":"Sai\u2010Zhen","family":"Zeng","sequence":"first","affiliation":[{"name":"Hunan provincial People's Hospital Changsha China"},{"name":"National Institute for Viral Disease Control and Prevention China CDC Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni\u2010Guang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Hunan provincial People's Hospital Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Li","family":"Zhong","sequence":"additional","affiliation":[{"name":"Hunan provincial People's Hospital Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Yu","sequence":"additional","affiliation":[{"name":"Hunan provincial People's Hospital Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hunan provincial People's Hospital Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao\u2010Jun","family":"Duan","sequence":"additional","affiliation":[{"name":"National Institute for Viral Disease Control and Prevention China CDC Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/499310"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23213"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2005.01.020"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2008.03.029"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23931"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204630"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/v4112754"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.10.002"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0903.020289"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1128\/jcm.31.7.1886-1891.1993","article-title":"Detection of adenovirus in clinical specimens by polymerase chain reaction and liquid\u2010phase hybridization quantitated by time\u2010resolved fluorometry","volume":"31","author":"Hierholzer JC","year":"1993","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1201.050772"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2011.09.004"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23438"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/421120"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0906.030009"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21884"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088342"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/89098"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/379200"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000108190.09824.e8"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/504378"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2012.07.007"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23501"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21194"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00809-12"},{"key":"e_1_2_5_27_1","first-page":"1623","article-title":"Characterization of human metapneumovirus from pediatric patients with acute respiratory infections in a 4\u2010year period in Beijing","volume":"124","author":"Zhu RN","year":"2011","journal-title":"China. 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