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Although symptoms are often mild, the concern is centralized around the possible effect on a fetus growth and development in case of primary infection during early months of pregnancy. Recently acquired rubella is commonly confirmed by RV\u2010specific IgM antibody detection in the serum. However, rubella primary infection is not always the only cause of IgM positivity. Other possible causes of rubella IgM positivity may include IgM persistence following vaccination or naturally acquired infection or even re\u2010infection. Moreover, nonspecific IgM reactivity can cause false\u2010positive results. There are few articles to differentiate the aetiology of rash in rubella\u2010like illnesses. However, limited studies have been conducted on clarifying the source of IgM positivity in these cases. This article reports the study of 10,896 clinical cases demonstrating rubella\u2010like illness between 2011 and 2013 in Iran. The rate of IgM positivity among these cases was 0.52% (57 cases). As predicted based on the high coverage of vaccination in Iran fewer than 16% of cases with ELISA IgM positive result, were due to current rubella primary infections. The greater part of the positive IgM reactions occurred in cross reactivity with other viruses (31.6%) or in prolonged IgM response post vaccination (24.6%). This research confirmed that the positive result of rubella IgM assay in vaccinated individuals is mainly caused by prolonged IgM production, rubella re\u2010infection, and false positivity due to infection with other viruses, rather than the rubella primary infection itself. <jats:bold><jats:italic>J. Med. Virol. 87:1846\u20131852, 2015<\/jats:italic>.<\/jats:bold> \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24250","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T22:59:13Z","timestamp":1430953153000},"page":"1846-1852","source":"Crossref","is-referenced-by-count":8,"title":["The etiology of Rubella IgM positivity in patients with rubella\u2010like illness in Iran from 2011 to 2013"],"prefix":"10.1002","volume":"87","author":[{"given":"Seyed Mahmood","family":"Seyed Khorrami","sequence":"first","affiliation":[{"name":"Virology Department School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talat","family":"Mokhtari\u2010Azad","sequence":"additional","affiliation":[{"name":"Virology Department School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jila","family":"Yavarian","sequence":"additional","affiliation":[{"name":"Virology Department School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gazal Sadat","family":"Fatemi Nasab","sequence":"additional","affiliation":[{"name":"Virology Department School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Naseri","sequence":"additional","affiliation":[{"name":"Virology Department School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazanin Zahra","family":"Shafiei Jandaghi","sequence":"additional","affiliation":[{"name":"Virology Department School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"38","article-title":"Detection of serum antibodies against Measles, Mumps and Ru\u2010bella after Primary Measles, Mumps and Rubella (MMR) vaccina\u2010tion in children","volume":"16","author":"Abdoul\u2010Reza Esteghamati M","year":"2013","journal-title":"Arch Iran Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01231-08"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21621"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.04.059"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-406"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.23260"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.6.12.13398"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00380-08"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","unstructured":"J.M.Best. 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