{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T18:38:39Z","timestamp":1771612719716,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T00:00:00Z","timestamp":1437350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Viral meningitis is the most common cause of aseptic meningitis. Use of the polymerase chain reaction (PCR) has increased the ability to determine the etiology of viral meningitis. This study used PCR analysis to evaluate the etiology of aseptic meningitis in 177 previously healthy adults over a 5\u2010year period, as well as analyzing the clinical characteristics, cerebrospinal fluid (CSF) findings, and prognosis according to each etiology. The most frequent cause of aseptic meningitis was enterovirus (EV), followed by varicella zoster virus (VZV). Patients with EV meningitis were significantly younger than those with VZV meningitis. The percentage of lymphocytes in white blood cell counts and protein concentrations in the CSF differed significantly among patients with EV, VZV and meningitis of undetermined etiology. Younger age and lower percentage of lymphocyte and protein level in CSF analysis may be suggestive of EV meningitis. Further prospective studies are warranted to identify the correlations between the clinical characteristics and the etiologies of meningitis. <jats:bold><jats:italic>J. Med. Virol. 88:175\u2013179, 2016<\/jats:italic>.<\/jats:bold> \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24316","type":"journal-article","created":{"date-parts":[[2015,6,27]],"date-time":"2015-06-27T23:03:24Z","timestamp":1435446204000},"page":"175-179","source":"Crossref","is-referenced-by-count":40,"title":["Etiology of aseptic meningitis and clinical characteristics in immune\u2010competent adults"],"prefix":"10.1002","volume":"88","author":[{"given":"Su\u2010Hyun","family":"Han","sequence":"first","affiliation":[{"name":"Department of Neurology, Asan Medical Center Ulsan University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye\u2010Yeon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gangdong Kyung Hee University Hospital Kyung Hee University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Chung\u2010Ang University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang\u2010Ryul","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Chung\u2010Ang University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Chul","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Neurology Chung\u2010Ang University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae\u2010Won","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology Chung\u2010Ang University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00862-11"},{"key":"e_1_2_5_3_1","first-page":"41","article-title":"Polymerase chain reaction for diagnosis of varicella zoster virus central nervous system infections without skin manifestations","volume":"100","author":"Bergstrom T","year":"1996","journal-title":"Scand J Infect Dis Suppl"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874357901206010104"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23470"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0b013e3283101866"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890430403"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02233.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(98)00048-8"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(02)00031-8"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/591129"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2008.03.003"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000191407.81333.00"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23192"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.8.817"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2003.00575.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq066"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1155\/2012\/378432","article-title":"Clinical presentation of patients with aseptic meningitis, factors influencing treatment and hospitalization, and consequences of enterovirus cerebrospinal fluid polymerase chain reaction testing","volume":"23","author":"Patriquin G","year":"2012","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.4.971"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2014.02.015"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(02)00030-6"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.24316","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.24316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:33:51Z","timestamp":1696390431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.24316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,20]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1002\/jmv.24316"],"URL":"https:\/\/doi.org\/10.1002\/jmv.24316","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,20]]}}}