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In 3,047 normal subjects, the overall prevalence across all HPV types was 25%, while that of the common 13 high\u2010risk (Common\u201013HR) types (HPV\u201016, 18. 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68) was 17%, and that of the definite high\u2010risk (Definite\u2010HR) types (HPV\u201016, 18. 31, 33, 35, 45, 52, and 58) was 12%. For Definite\u2010HR, HPV\u201052, 16, and 58 were the most common, HPV\u201031 was relatively common, and HPV\u201018 was less common, while HPV\u201033, 35, and 45 were rare. Seven Definite\u2010HR excluding HPV\u201045 and seven Possible\u2010HR (HPV\u201039, 51, 56, 66, 68, 70, and 82) HPV types were identified as a single type infection in patients with high\u2010grade squamous intraepithelial lesion (HSIL) or worse. The Common\u201013HR types were detected in 89% of subjects with HSIL, whereas either Definite\u2010HR or Possible\u2010HR types were detected in 95% of HSIL. These 1420 HPV types appear to be involved with HSIL or worse in Japan. The prevalences of multiple\u2010type HPV infections were identified in roughly half of HPV\u2010positive subjects, and decreased significantly with age in normal population and abnormal cytology groups, although the prevalences of single\u2010type infections increased with age in the latter group. Most HPV infections are cleared for some years, while a certain HR\u2010HPV type persists to induce HSIL. <jats:bold><jats:italic>J. Med. 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