{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:57:00Z","timestamp":1762606620327},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grants funded by the Korea government (MSIP)","award":["2011-0030043"],"award-info":[{"award-number":["2011-0030043"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:label \/><jats:p>Studies about long\u2010term entecavir (ETV) therapy for partial virological response (PVR) are lacking. This study aimed to assess the clinical course of PVR patients receiving ETV therapy and analyze the efficacy of tenofovir (TDF). We retrospectively evaluated 130 patients who showed a PVR to ETV. Among these patients, 102 were nucleot(s)ide analogue (NUC)\u2010na\u00efve and 28 were lamivudine (LAM)\u2010experienced. The cumulative rates of VR were 54.1%, 70.8%, and 83.7% for the NUC\u2010na\u00efve group and 37.0%, 42.8%, and 42.8% for the LAM\u2010experienced group after 24, 36, and 48 months of ETV therapy, respectively (<jats:italic>P<\/jats:italic> \u2009=\u20090.008). Low HBV DNA level at 12 months (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001) and absence of a LAM treatment history (<jats:italic>P \u2009<\/jats:italic>=\u20090.031) were significant associated factors for VR. In VR prediction at 36 months of ETV therapy in NUC\u2010na\u00efve patients, HBV DNA level &lt;95\u2009IU\/ml at 12 months showed a 92.9% sensitivity and a 78.3% specificity (AUROC, 0.909; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). ETV resistance did not develop in NUC\u2010na\u00efve patients with HBV DNA levels &lt;95\u2009IU\/ml at 12 months. The cumulative probability of VR in patients who switched to or additionally received TDF was 91.3% at 15 months. Prolonged ETV therapy induced a VR without the risk of ETV resistance in NUC\u2010na\u00efve patients with HBV DNA levels &lt;95\u2009IU\/ml at 12 months. All patients with LAM\u2010experienced or NUC\u2010na\u00efve with HBV DNA levels \u226595\u2009IU\/ml at 12 months should be switched to TDF rescue therapy. <jats:bold><jats:italic>J. Med. Virol. 88:252\u2013259, 2016<\/jats:italic>.<\/jats:bold> \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24330","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T21:26:54Z","timestamp":1436909214000},"page":"252-259","source":"Crossref","is-referenced-by-count":2,"title":["Clinical course of partial virological responders under prolonged entecavir monotherapy in patients with chronic hepatitis B"],"prefix":"10.1002","volume":"88","author":[{"given":"Joo Han","family":"Park","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ajou University School of Medicine Suwon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon Joo","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ajou University School of Medicine Suwon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Jung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ajou University School of Medicine Suwon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon","family":"Sun Kim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ajou University School of Medicine Suwon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Youn","family":"Cheong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ajou University School of Medicine Suwon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Won","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ajou University School of Medicine Suwon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2013.05.001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12239"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01161.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.010"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12629"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22900"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.09.020"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.01.006"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23440"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i47.6996"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.719927"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2013.7.6.712"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3282f793d6"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.5472"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S4188"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01533.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22841"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23246"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2402-2"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.27563"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(12)60012-9"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24406"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.24330","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.24330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:28:43Z","timestamp":1696336123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.24330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,23]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1002\/jmv.24330"],"URL":"https:\/\/doi.org\/10.1002\/jmv.24330","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,23]]}}}