{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:45:45Z","timestamp":1759009545620},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T00:00:00Z","timestamp":1439942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Instituto de Investigaciones Cl\u00ednicas \u201cDr. Am\u00e9rico Negrette\u201d, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela. CONDES, Universidad del Zulia, Maracaibo, Venezuela"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:label \/><jats:p>C\u2010reactive protein (CRP) is an acute\u2010phase reactant that increases in the circulation in response to a variety of inflammatory stimuli. Elevated levels in serum during several infectious diseases have been reported. In this study, a highly sensitive CRP enzyme immunoassay was used to evaluate serum CRP values in patients with viral and atypical bacterial infections. Patients (n\u2009=\u2009139) with different viral or atypical bacterial infections (systemic or respiratory) and healthy controls (n\u2009=\u200940) were tested for circulating CRP values. High levels of IgM antibodies against several viruses: Dengue virus (n\u2009=\u200936), <jats:italic>Cytomegalovirus<\/jats:italic> (n\u2009=\u20099), Epstein Barr virus (n\u2009=\u200917), <jats:italic>Parvovirus B19<\/jats:italic> (n\u2009=\u200926), <jats:italic>Herpes simplex 1 and 2 virus<\/jats:italic> (n\u2009=\u20093) and <jats:italic>Influenza A and B<\/jats:italic> (n\u2009=\u20098) and against atypical bacteria: <jats:italic>Legionella pneumophila<\/jats:italic> (n\u2009=\u200915)<jats:italic>, Mycoplasma pneumoniae<\/jats:italic> (n\u2009=\u200921) and <jats:italic>Coxiella burnetii<\/jats:italic> (n\u2009=\u20094) were found. High values of CRP in infected patients compared with controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were found; however, no significant differences between viral and atypical bacterial infections were found. Low levels of CRP in respiratory and <jats:italic>Coxiella burnetii<\/jats:italic> infections compared with exanthematic viral and other atypical bacterial infections were found. This study suggests that CRP values are useful to define viral and atypical bacterial infections compared with normal values, but, it is not useful to define type of infection. <jats:bold><jats:italic>J. Med. Virol. 88:351\u2013355, 2016<\/jats:italic>.<\/jats:bold> \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24341","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T13:41:42Z","timestamp":1438695702000},"page":"351-355","source":"Crossref","is-referenced-by-count":11,"title":["Serum level of C\u2010reactive protein is not a parameter to determine the difference between viral and atypical bacterial infections"],"prefix":"10.1002","volume":"88","author":[{"given":"Anyelo","family":"Dur\u00e1n","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Cl \u00ed nicas \u201cDr. Am \u00e9 rico Negrette\u201d. Facultad de Medicina Universidad del Zulia Maracaibo Zulia Venezuela"},{"name":"C\u00e1tedra de Bioqu\u00edmica General Escuela de Bioan\u00e1lisis. Facultad de Medicina Universidad del Zulia Maracaibo Zulia Venezuela"},{"name":"Sociedad Venezolana de Microbiolog\u00eda Maracaibo Zulia Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cl \u00ed nicas \u201cDr. Am \u00e9 rico Negrette\u201d. Facultad de Medicina Universidad del Zulia Maracaibo Zulia Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lineth","family":"Delgado","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cl \u00ed nicas \u201cDr. Am \u00e9 rico Negrette\u201d. Facultad de Medicina Universidad del Zulia Maracaibo Zulia Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Mosquera","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Bioqu\u00edmica General Escuela de Bioan\u00e1lisis. Facultad de Medicina Universidad del Zulia Maracaibo Zulia Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nereida","family":"Valero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cl \u00ed nicas \u201cDr. Am \u00e9 rico Negrette\u201d. Facultad de Medicina Universidad del Zulia Maracaibo Zulia Venezuela"},{"name":"Sociedad Venezolana de Microbiolog\u00eda Maracaibo Zulia Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.10.4.652-657.2003"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102466\u201014\u2010123"},{"key":"e_1_2_5_4_1","first-page":"1","article-title":"Thoracic Society Guidelines for the management of community acquired pneumonia in childhood. 2002. british thoracic society standards of care committee","volume":"57","author":"British","journal-title":"Thorax Suppl"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840120517"},{"key":"e_1_2_5_6_1","first-page":"4855","article-title":"Diagnostic value of C\u2010reactive protein in bacterial infections","volume":"160","author":"Dahler\u2010Eriksen BS","year":"1998","journal-title":"Rev Lit Ugeskr Laeger"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318174e0e8"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102466\u201014\u2010150"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.12.1733"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.3.480"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2650621"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2014.04.014"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00625-08"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-65"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.1.64"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1446"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.at1010"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/591393"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.09.131"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61459-6"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/61.1.247"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/422996"},{"key":"e_1_2_5_23_1","first-page":"61","article-title":"Programa de atenci\u00f3n primaria para infecci\u00f3n respiratoria aguda aplicado a nivel terciario\/Program of primary attention to acute respiratory infection applied in the terciary level","volume":"1","author":"Urbano\u2010 Rosales G","year":"1992","journal-title":"Medula"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb22140.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(01)00042-6"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-007-0496-x"},{"key":"e_1_2_5_27_1","volume-title":"Dengue guidelines for diagnosis, treatment, prevention and control Third edition","author":"WHO","year":"2009"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/513803"},{"key":"e_1_2_5_29_1","first-page":"2245","article-title":"Identification of a C\u2010reactive protein binding site in two hepatic carboxylesterases capable of retaining C\u2010reactive protein within the endoplasmic reticulum","volume":"271","author":"Yue CC","year":"1996","journal-title":"J Biol Chem"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.24341","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.24341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:29:32Z","timestamp":1696336172000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.24341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,19]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1002\/jmv.24341"],"URL":"https:\/\/doi.org\/10.1002\/jmv.24341","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,19]]}}}