{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:10:46Z","timestamp":1789834246436,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Research in Virology and Biotechnology"},{"name":"Secretar\u00eda Nacional de Ciencias, Tecnolog\u00eda e Innovaci\u00f3n Panam\u00e1 (SENACYT)","award":["CAP10-001"],"award-info":[{"award-number":["CAP10-001"]}]},{"name":"Columbus University Contract","award":["CU-VIP-P-003-2014"],"award-info":[{"award-number":["CU-VIP-P-003-2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>The human bocavirus (HBoV) was added as a new member of the <jats:italic>Parvoviridae<\/jats:italic> family in 2005 upon its discovery in nasopharyngeal aspirates from children with respiratory infection. Recently, there has been increasing evidence of worldwide circulation of HBoV; however, in Latin America few studies have been conducted. In order to detect the circulation of HBoV in Panama, based on the National Flu Surveillance System, we developed this retrospective, cross\u2010sectional study, from January 2011 to January 2012. Children younger than 6 years old who presented with respiratory disease were enrolled in this study. Nasopharyngeal swabs were taken in sentinel surveillance sites. Samples were tested to detect mRNA from HBoV, as well as viral RNA and DNA from others respiratory viruses. A total of 1078 patients were enrolled in this study. Overall, 44 (4.1%) of the patients presented HBoV. The most common symptoms were cough (84.6%), fever (82.1%), rhinorrhea (74.4%), and sore throat (38.5%). Less than half (45.5%) of HBoV infected patients presented with monoinfection while 54.5% of cases presented with coinfection with others respiratory viruses. Both, outpatients and inpatients were included in this study. Outpatients corresponded to 52.3% of the cases and 47.7% were inpatients. Coinfection was observed in the 50% of the inpatient cases. Phylogenetic analyses indicated that the circulating strains belonged to different clades of HBoV genotype 1. Taken together, our results support the pathogenic nature of this viral agent, especially in younger children. <jats:bold><jats:italic>J. Med. Virol. 88:389\u2013394, 2016<\/jats:italic>.<\/jats:bold> \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24346","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:58:57Z","timestamp":1438948737000},"page":"389-394","source":"Crossref","is-referenced-by-count":12,"title":["Detection of Human Bocavirus Type 1 infection in Panamanian children with respiratory illness"],"prefix":"10.1002","volume":"88","author":[{"given":"Brechla","family":"Moreno","sequence":"first","affiliation":[{"name":"Deparment of Research in Virology and Biotechnology Gorgas Memorial Institute of Health Studies Panama City Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyda","family":"Abrego","sequence":"additional","affiliation":[{"name":"Deparment of Research in Virology and Biotechnology Gorgas Memorial Institute of Health Studies Panama City Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"Carrera","sequence":"additional","affiliation":[{"name":"Deparment of Research in Virology and Biotechnology Gorgas Memorial Institute of Health Studies Panama City Panama"},{"name":"Department of Pre\u2010Clinical Sciences School of Medicine, Columbus University Panama City Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Franco","sequence":"additional","affiliation":[{"name":"Deparment of Research in Virology and Biotechnology Gorgas Memorial Institute of Health Studies Panama City Panama"},{"name":"Department of Microbiology, School of Medicine University of Panama Panama City Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Gait\u00e1n","sequence":"additional","affiliation":[{"name":"Deparment of Research in Virology and Biotechnology Gorgas Memorial Institute of Health Studies Panama City Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Genomic and Proteomic Gorgas Memorial Institute of Health Studies Panama City Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Pascale","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine University of Panama Panama City Panama"},{"name":"Department of Genomic and Proteomic Gorgas Memorial Institute of Health Studies Panama City Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Arbiza","sequence":"additional","affiliation":[{"name":"Virology Section, School of Sciences University of the Republic Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504666102"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000391"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018928"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181694fb9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00545-07"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-5-113"},{"key":"e_1_2_5_8_1","first-page":"504","article-title":"Human bocavirus in Chile: clinical characteristics and epidemiological profile in children with acute respiratory tract infections","volume":"28","author":"Flores CJC","year":"2011","journal-title":"Rev Chil Infectol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02719-09"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/595831"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1402.070851"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/652405"},{"key":"e_1_2_5_13_1","first-page":"70","article-title":"Human bocavirus respiratory infection in infants in C\u00f3rdoba, Argentina","volume":"112","author":"Moreno L","year":"2014","journal-title":"Arch Argent Pediatr"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00027-07"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021083"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041967"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.11.136"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst197"},{"key":"e_1_2_5_19_1","first-page":"1277","article-title":"Prevalence and genotypes of the adenovirus infection as well detection of co\u2010infection with bocavirus in Mexican immunosuppressed and non\u2010immunosuppressed children with pneumonia","volume":"60","author":"Uribe G","year":"2014","journal-title":"Clin Lab"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.07.017"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062318"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.24346","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.24346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T10:33:59Z","timestamp":1696588439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.24346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,19]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/jmv.24346"],"URL":"https:\/\/doi.org\/10.1002\/jmv.24346","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,19]]}}}