{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T22:55:31Z","timestamp":1782600931332,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>Secondary hemophagocytic lymphohistiocytosis (SHLH) is a potentially fatal hyperinflammatory syndrome with a heterogeneous etiology and has nonspecific clinical and laboratory findings. The diagnosis and treatment of adult SHLH is challenging because the etiology of the disease is difficult to identify, and the majority of reported cases are pediatric patients. The aim of this study was to describe the etiology, clinical characteristics, and outcomes of adult SHLH. Fifty\u2010four adult patients who fulfilled the criteria of SHLH were enrolled in the study. Viral etiology, blood biomarkers, and clinical manifestations of SHLH were analyzed in these patients. Twenty\u2010four SHLH patients had viraemia, whereas 30 SHLH patients were secondary to other diseases. Epstein\u2010Barr virus (EBV) was the most common virus that associated SHLH among all viruses studied. Severe SHLH patients with EBV\u2010viraemia presented significantly high levels of ferritin, lactate dehydrogenase, aspartate transaminase (AST), and alanine transaminase (ALT). Positively relationships existed between EBV DNA titers and levels of AST and ALT (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.05). The prognosis of SHLH patients with EBV viraemia was worse than that of non\u2010EBV SHLH and non\u2010viral SHLH. Our data reveal that EBV is the major pathogen in virus\u2010associated SHLH, and EBV load influence disease development in SHLH patients with EBV infection that prognosis is worse than other viruses associated SHLH. <jats:bold><jats:italic>J. Med. Virol. 88:541\u2013549, 2016<\/jats:italic>.<\/jats:bold> \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.24359","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T23:44:12Z","timestamp":1440027852000},"page":"541-549","source":"Crossref","is-referenced-by-count":18,"title":["Viral etiology, clinical and laboratory features of adult hemophagocytic lymphohistiocytosis"],"prefix":"10.1002","volume":"88","author":[{"given":"Jinghong","family":"Chen","sequence":"first","affiliation":[{"name":"Shantou Center for Disease Control and Prevention Shantou Guangdong China"},{"name":"Cell Biology and Genetics Department of Shantou University Medical College Shantou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital of Shantou University Medical College Shantou Guangdong 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